The Access Core ofthe SPOTRIAS center at Partners will continue to support the rapid administration of standard intravenous thrombolysis, the rapid evaluation and treatment of hemorrhagic stroke, as well as the execution of the four proposed research projects (two independent Partners projects and two collaborative projects with Columbia University) at the two Partners academic centers. The Access Core will also strive to increase its impact on stroke in the broader community by extending its acute stroke expertise within and across our extensive network of Partners Healthcare System (PHS) and 26 TeleStroke-affiliated hospitals. This will help provide a platform from which to launch future SPOTRIAS network-wide stroke research. For the last two decades. Partners has enjoyed a rich clinical and research collaboration involving the Departments of Emergency Medicine, Radiology, Neurology, and Neurosurgery. The leadership of the Access Core reflects the integrated approach to acute stroke care across the system. The Access Core is co-directed by physicians from Neurology and Emergency Medicine who are institutional leaders in quality improvement, with additional key leadership positions held by active members of these departments at each site, all of whom care for acute stroke patients in their clinical practice. In addition, the two hospitals use the same acute stroke protocols, share the same acute stroke and NICU fellows and collaborate on the same acute stroke quality agenda. The Partners SPOTRIAS program is fully integrated into the daily activities of the clinical stroke care and stroke research activities at the two sites, and the Access Core is uniquely positioned to accomplish its goals because so many of the SPOTRIAS research faculties are also active members ofthe acute stroke clinical care delivery team. In pursuit of its aims, the Access Core will utilize the robust quality improvement infrastructure which Dr. Schwamm has developed across Partners for continued advancement of acute stroke care for patients within the broader context of a coordinated regional stroke network.

Public Health Relevance

Stroke is a disabling disease of major public health importance. New treatments are desperately needed to improve health outcomes for the more than 700,000 patients who experience a stroke each year. In addition, current data suggest that many patients who might benefit from intravenous thrombolysis and other proven interventions do not receive them. It is of vital importance to identify and disseminate best practices in the delivery of acute stroke care, and to pioneer new therapies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS051343-09
Application #
8484459
Study Section
Special Emphasis Panel (ZNS1-SRB-R)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$222,667
Indirect Cost
$90,043
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Rost, Natalia S; Cougo, Pedro; Lorenzano, Svetlana et al. (2018) Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab 38:75-86
Lorenzano, Svetlana; Rost, Natalia S; Furie, Karen L (2018) Response by Lorenzano et al to Letter Regarding Article, ""Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke"". Stroke 49:e264
Matsouaka, Roland A; Singhal, Aneesh B; Betensky, Rebecca A (2018) An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res 27:2384-2400
Lorenzano, Svetlana; Rost, Natalia S; Khan, Muhib et al. (2018) Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke. Stroke 49:630-637
Murphy, Meredith P; Kuramatsu, Joji B; Leasure, Audrey et al. (2018) Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 49:2652-2658
Schwamm, Lee H; Wu, Ona; Song, Shlee S et al. (2018) Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results. Ann Neurol 83:980-993
Atem, Folefac D; Qian, Jing; Maye, Jacqueline E et al. (2017) Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study. J R Stat Soc Ser C Appl Stat 66:313-328
Dumitrascu, Oana M; Torbati, Sam; Tighiouart, Mourad et al. (2017) Pitfalls and Rewards for Implementing Ocular Motor Testing in Acute Vestibular Syndrome: A Pilot Project. Neurologist 22:44-47
Marini, Sandro; Morotti, Andrea; Ayres, Alison M et al. (2017) Sex differences in intracerebral hemorrhage expansion and mortality. J Neurol Sci 379:112-116
Etherton, Mark R; Wu, Ona; Cougo, Pedro et al. (2017) Structural Integrity of Normal Appearing White Matter and Sex-Specific Outcomes After Acute Ischemic Stroke. Stroke 48:3387-3389

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