The Statistics and Data Management Core will provide essential support for statistical analysis and data management for the three projects proposed in this application. For the past 25 years, the Biostatistics Unit at the Feinstein Institute for Medical Research has collaborated with investigators at the NSLIJ Health System and other Institutes in Phase 1,11 and 111 trials that are sponsored by NIH or by pharmaceutical companies. Dr. Martin Lesser, the Core Learder and the Director of the Biostatistics Unit, and other Core members have extensive experience in the design, data management, and analysis of clinical research projects/trials. This core consists of two components. The Biostatistics component will support Project teams of all three Projects by providing statistical advice in study design, data analysis and interpretation. Additionally, for the Project 3, the Core will explore new methods of statistical classification for differential diagnosis of patients with parkinsonism. The other component ofthe Core is Data Management, which will have primary responsibility forthe development and maintenance ofthe data management system and procedures for all the projects in this application. Support will be provided in many areas including case report form development, data entry, database programming, database query, data quality assurance, report production, auditing, etc.
This Core will assist the Project team in statistical analysis and data management for the three proposed projects, which aim to improve our understanding on pathophysiology, treatment responses, and differential diagnosis for patients with parkinsonism.
|Ko, Ji Hyun; Lerner, Renata P; Eidelberg, David (2015) Effects of levodopa on regional cerebral metabolism and blood flow. Mov Disord 30:54-63|
|Peng, Shichun; Ma, Yilong; Spetsieris, Phoebe G et al. (2014) Characterization of disease-related covariance topographies with SSMPCA toolbox: effects of spatial normalization and PET scanners. Hum Brain Mapp 35:1801-14|
|Peng, Shichun; Eidelberg, David; Ma, Yilong (2014) Brain network markers of abnormal cerebral glucose metabolism and blood flow in Parkinson's disease. Neurosci Bull 30:823-37|
|Ko, Ji Hyun; Feigin, Andrew; Mattis, Paul J et al. (2014) Network modulation following sham surgery in Parkinson's disease. J Clin Invest 124:3656-66|
|Holtbernd, Florian; Gagnon, Jean-François; Postuma, Ron B et al. (2014) Abnormal metabolic network activity in REM sleep behavior disorder. Neurology 82:620-7|
|Tomer, Rachel; Slagter, Heleen A; Christian, Bradley T et al. (2014) Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment. J Cogn Neurosci 26:1039-48|
|Ko, Ji Hyun; Spetsieris, Phoebe; Ma, Yilong et al. (2014) Quantifying significance of topographical similarities of disease-related brain metabolic patterns. PLoS One 9:e88119|
|Holtbernd, Florian; Eidelberg, David (2014) The utility of neuroimaging in the differential diagnosis of parkinsonian syndromes. Semin Neurol 34:202-9|
|Papay, Kimberly; Xie, Sharon X; Stern, Matthew et al. (2014) Naltrexone for impulse control disorders in Parkinson disease: a placebo-controlled study. Neurology 83:826-33|
|Spetsieris, Phoebe; Ma, Yilong; Peng, Shichun et al. (2013) Identification of disease-related spatial covariance patterns using neuroimaging data. J Vis Exp :|
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