Abstract

? Vector-Borne Diseases Core The Vector-Borne Diseases Core produces tick vectors for research on Lyme disease and other tick-borne diseases. All of the developmental stages of the hard tick Ixodes scapularis are available for research purposes. The Core is run by Mary Jacobs, MS, under the direction of Monica Morici-Embers, PhD. During the last funding period, the Core made useful improvements to the techniques of tick feeding on animals. These changes facilitated the use of xenodiagnosis, a procedure that is very sensitive for detection of living spirochetes in animals with low-level infections. The types of services provided include the provision of ticks for: 1) Tick- mediated infection, 2) Capillary feeding of ticks, 3) Xenodiagnosis, and 4) Collection of tick saliva. All of the service capabilities of the Core were utilized this funding period, and a large number of ticks (6720) were generated. The Core has been very productive and has fostered a large number of collaborations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
2P51OD011104-57
Application #
9568198
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
57
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Tulane University
Department
Type
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118

  Publications

He, Ziyuan; Allers, Carolina; Sugimoto, Chie et al. (2018) Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. J Immunol 200:4059-4067
Pan, Diganta; Das, Arpita; Srivastav, Sudesh K et al. (2018) Lack of T-cell-mediated IL-2 and TNF? production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection. J Gen Virol :
Kuroda, Marcelo J; Sugimoto, Chie; Cai, Yanhui et al. (2018) High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Infect Dis 217:1865-1874
Laddy, Dominick J; Bonavia, Aurelio; Hanekom, Willem A et al. (2018) Toward Tuberculosis Vaccine Development: Recommendations for Nonhuman Primate Study Design. Infect Immun 86:
McNamara, Ryan P; Costantini, Lindsey M; Myers, T Alix et al. (2018) Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses. MBio 9:
Veazey, Ronald S; Lu, Yingjie; Xu, Huanbin et al. (2018) Maternal antibodies against tetanus toxoid do not inhibit potency of antibody responses to autologous antigen in newborn rhesus monkeys. J Med Primatol 47:35-39
Perez, Stefanie; Johnson, Ann-Marie; Xiang, Shi-Hua et al. (2018) Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy. J Neurovirol 24:62-74
Crossland, Nicholas A; Alvarez, Xavier; Embers, Monica E (2018) Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques. Am J Pathol 188:672-682
Gautam, Uma S; Foreman, Taylor W; Bucsan, Allison N et al. (2018) In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 115:E62-E71
Calenda, Giulia; Keawvichit, Rassamon; Arrode-Brusés, Géraldine et al. (2018) Integrin ?4?7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques. J Immunol 200:810-820

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