The current application proposes follow-up of a sample for a funded Genome-wide Association Study (GWAS) of alcohol dependence (1799 alcohol dependent cases and 1808 controls). This cohort, which has a demonstrated commitment to research participation of more than a decade, is unique in that is comprised of individuals who were ascertained from prior community-based (rather than clinical) assessment and who grew up during a period of very restrictive Australian divorce laws so that 85% of those reporting a history of parental alcoholism were raised by both biological parents through age 16. The project's aims are:
AIM1 To assess lifetime history of severe childhood and adult environmental stressors, DSM-IV lifetime diagnoses of PTSD and illicit drug dependence, and updated histories of alcohol consumption measures and DSM-IV alcohol dependence in this sample of Australians for whom whole genome SNP genotyping is in progress AIM2 Using a quantitative heaviness of drinking factor score, to test for moderation of SNP genotype effects by history of severe childhood stressors AIMS To test for moderation of SNP genotype effects on alcohol dependence symptoms by history of severe childhood stressors The current application draws on data from the project director's recently-completed Trauma Study (AA13446) which comprehensively assessed severe childhood stressors in a partially-overlapping sample of twins and siblings. We present data demonstrating the feasibility (section 3.2) of the assessment (on which the current proposal's assessment is based) including strong evidence for its utility in collecting retrospective history of childhood events (i.e excellent within-pair agreement for same-sex twins), and the ability to derive factors from its use that have excellent psychometric properties (section 3.3), display a dose-response realtionship with report of parental alcohol problems (section 3.4), and which contribute significantly to the proposal's primary dependent measure, a quantitative alcohol consumption factor (section 3.5). We believe that the proposed design is uniquely well-suited to uncover G x E interactions contributing to the liability for alcohol consumption and has adequate power for this purpose (section 4.5).

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011998-14
Application #
8375818
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
14
Fiscal Year
2012
Total Cost
$301,970
Indirect Cost
$21,596
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2017) Sleeve gastrectomy surgery: When 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis :
Otto, Jacqueline M; Gizer, Ian R; Deak, Joseph D et al. (2017) A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clin Exp Res 41:929-938
Von Gunten, Curtis D; Volpert-Esmond, Hannah I; Bartholow, Bruce D (2017) Temporal dynamics of reactive cognitive control as revealed by event-related brain potentials. Psychophysiology :
Agrawal, A; Chou, Y-L; Carey, C E et al. (2017) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry :
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2017) Inhibitory Control in Siblings Discordant for Exposure to Maternal Smoking During Pregnancy. Dev Psychol :
Carpenter, Ryan W; Trela, Constantine J; Lane, Sean P et al. (2017) Elevated rate of alcohol consumption in borderline personality disorder patients in daily life. Psychopharmacology (Berl) 234:3395-3406
Martins, Jorge S; Bartholow, Bruce D; Cooper, M Lynne et al. (2017) Associations Between Executive Functioning, Affect-Regulation Drinking Motives, and Alcohol Use and Problems. Psychol Addict Behav :
Sadler, Brooke E; Grant, Julia D; Duncan, Alexis E et al. (2017) The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood. J Stud Alcohol Drugs 78:426-434
Hone, Liana S E; Bartholow, Bruce D; Piasecki, Thomas M et al. (2017) Women's Alcohol Sensitivity Predicts Alcohol-Related Regretted Sex. Alcohol Clin Exp Res 41:1630-1636
Korucuoglu, Ozlem; Sher, Kenneth J; Wood, Phillip K et al. (2017) Acute alcohol effects on set-shifting and its moderation by baseline individual differences: a latent variable analysis. Addiction 112:442-453

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