A strong Administrative Core is essential to the proposed Center for Health And Risk in Minority youth and adults (CHARM). CHARM brings together key personnel across 3 Schools at UCSF (Medicine, Pharmacy, Nursing), across multiple departments within the School of Medicine (Medicine, Pediatrics, Family and Community Medicine, Obstetrics and Gynecology, Epidemiology and Biostatistics) and across multiple geographical locations at UCSF (including San Francisco General Hospital). CHARM also partners with San Francisco State University (SFSU) and includes key personnel from Northern California Kaiser Permanente Division of Research, UC Berkeley, and Stanford University. This broad investigative team, with its multiple domains of expertise, has enthusiastically coalesced to achieve CHARM's goals to prevent chronic disease and associated risk behaviors in disparity populations in the SF Bay area through a focus on late childhood, adolescence and young adulthood (ages 8-35 years, hereafter "youth and young adults"). Chronic illnesses (e.g., diabetes, cardiovascular disease, asthma, obesity) are major sources of morbidity and mortality among racial/ethnic minority populations in the US. The youth and young adult period represents a crucial opportunity for the prevention of chronic disease in minority populations particulariy because many of these chronic conditions develop at younger ages in these populations. Despite this opportunity, this age group has not been the focus of major research efforts. The challenges of conducting high-quality research in minority populations - and additionally in youth and young adults - that will produce effective strategies for improving the health of these communities requires input from multiple disciplines. CHARM will link investigators with clinical expertise in medicine, pediatrics, family medicine, obstetrics and gynecology, and public health with those whose expertise encompasses methodological approaches to disparities research, genetics, epidemiology, biostatistics, health policy, communication sciences, and health psychology. This approach is essential to the conduct of high quality, ethical investigation into the biological, behavioral, and social factors that underiie risk of chronic disease in minority populations. It is equally vital to the design of effective culturally and ageappropriate prevention interventions.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Pino-Yanes, Maria; Thakur, Neeta; Gignoux, Christopher R et al. (2015) Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol 135:228-35
Pino-Yanes, Maria; Gignoux, Christopher R; Galanter, Joshua M et al. (2015) Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol 135:1502-10
Drake, Katherine A; Torgerson, Dara G; Gignoux, Christopher R et al. (2014) A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol 133:370-8
Royce, S; Khann, S; Yadav, R P et al. (2014) Identifying multidrug resistance in previously treated tuberculosis patients: a mixed-methods study in Cambodia. Int J Tuberc Lung Dis 18:1299-306
Szpiech, Zachary A; Hernandez, Ryan D (2014) selscan: an efficient multithreaded program to perform EHH-based scans for positive selection. Mol Biol Evol 31:2824-7
Rogers, Elizabeth A; Fine, Sarah; Handley, Margaret A et al. (2014) Development and early implementation of the bigger picture, a youth-targeted public health literacy campaign to prevent type 2 diabetes. J Health Commun 19 Suppl 2:144-60
Santos, Maricel G; Handley, Margaret A; Omark, Karin et al. (2014) ESL participation as a mechanism for advancing health literacy in immigrant communities. J Health Commun 19 Suppl 2:89-105
Myers, Rachel A; Scott, Nicole M; Gauderman, W James et al. (2014) Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet 23:5251-9
Poole, Alex; Urbanek, Cydney; Eng, Celeste et al. (2014) Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol 133:670-8.e12
Galanter, Joshua M; Gignoux, Christopher R; Torgerson, Dara G et al. (2014) Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. J Allergy Clin Immunol 134:295-305

Showing the most recent 10 out of 27 publications