The risk of extensive alcohol use is increased during adolescence, and attractiveness of ethanol at this age is based in part on its properties to produce social facilitation, since adolescence as a developmental period is characterized by a high significance of interactions with peers and high social motivation. An attenuated sensitivity to adverse effects of ethanol that normally serve to diminish drinking (including ethanol-induced social inhibition) could serve as a permissive factor for heavy drinking during adolescence. Animal studies have shown that adolescent rats, like their human counterparts, are extremely sensitive to activating effects of ethanol on social behavior and relatively insensitive to ethanol-induced behavioral suppression and social inhibition. Considerable ontogenetic differences in the social consequences of ethanol are evident even within the adolescent period, with early adolescence being a time of particularly pronounced adolescent-typical sensitivities to ethanol. In adult animals, endogenous opioid mechanisms have been shown to be involved in mediation of ethanol effects, with positive (stimulatory and reinforcing) properties of ethanol being related to mu receptors and adverse (aversive and inhibitory) effects of the drug being associated with kappa receptors. The present proposal uses an animal model of peer-directed social activity to investigate whether these opposing opioid mechanisms are likewise involved in mediation of the social consequences of ethanol and whether adolescent animals are more sensitive than adults to ethanol- induced activation of the mu opioid system and less sensitive than their adult counterparts to activation of the kappa opioid system. Using a psychopharmacological approach with receptor-selective opioid antagonists and agonists, experiments will be conducted to determine the effectiveness of opioid antagonists in reversing ethanol-induced social facilitation and social inhibition, and to compare the social consequences of opioid agonists in early, mid, and late adolescent as well as adult rats with previously characterized ontogenetic patterns of responsiveness to the stimulatory and inhibitory effects of ethanol on social behavior. The proposed work will provide information about substrates underlying the age-specific sensitivities of young adolescents to the social consequences of ethanol and their potential implications regarding the frequent initiation of ethanol use and high consumption levels at this age.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA012453-09
Application #
7798557
Study Section
Neurotoxicology and Alcohol Study Section (NAL)
Program Officer
Witt, Ellen
Project Start
1999-10-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
9
Fiscal Year
2010
Total Cost
$298,610
Indirect Cost
Name
State University of NY, Binghamton
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902
Morales, Melissa; Anderson, Rachel I; Spear, Linda P et al. (2014) Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. Dev Psychobiol 56:700-12
Varlinskaya, Elena I; Mooney, Sandra M (2014) Acute exposure to ethanol on gestational day 15 affects social motivation of female offspring. Behav Brain Res 261:106-9
Anderson, Rachel I; Morales, Melissa; Spear, Linda P et al. (2014) Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats. Psychopharmacology (Berl) 231:1687-93
Varlinskaya, Elena I; Vogt, Brent A; Spear, Linda P (2013) Social context induces two unique patterns of c-Fos expression in adolescent and adult rats. Dev Psychobiol 55:684-97
Varlinskaya, Elena I; Truxell, Eric M; Spear, Linda P (2013) Repeated restraint stress alters sensitivity to the social consequences of ethanol differentially in early and late adolescent rats. Pharmacol Biochem Behav 113:38-45
Morales, Melissa; Varlinskaya, Elena I; Spear, Linda P (2013) Anxiolytic effects of the GABA(A) receptor partial agonist, L-838,417: impact of age, test context familiarity, and stress. Pharmacol Biochem Behav 109:31-7
Cohen, Ori S; Varlinskaya, Elena I; Wilson, Carey A et al. (2013) Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci 31:740-50
Anderson, R I; Agoglia, A E; Morales, M et al. (2013) Stress, * manipulations, and aversive effects of ethanol in adolescent and adult male rats. Neuroscience 249:214-22
Varlinskaya, Elena I; Vetter-O'Hagen, Courtney S; Spear, Linda P (2013) Puberty and gonadal hormones: role in adolescent-typical behavioral alterations. Horm Behav 64:343-9
Varlinskaya, Elena I; Spear, Linda P (2012) Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats. Pharmacol Biochem Behav 100:440-50

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