Relevance: Alcohol and other drug use are common among U.S. adolescents. Our prior studies found that adolescents with alcohol use disorders (AUD) show abnormalities on indices .of brain functioning, including neuropsychological testing, hippocampal volume, and functional magnetic resonance imaging (FMRI) response to cognitive tasks. We also found abnormalities on some of these measures related to risk factors for adolescent alcohol involvement. Thus, it is unclear if abnormalities observed in adolescents with AUD are caused by alcohol exposure, or predated the onset of heavy drinking. Description: This renewal project will follow youth initially characterized in the first funding period of R01 AA13419. At baseline, these youth are 12-14 year-olds free from any psychiatric disorder with, on average, one alcohol use experience, and half are at risk for AUD based on a family history of alcohol dependence. Baseline assessment includes neuropsychological testing, high resolution MRI, and FMRI acquisition during spatial working memory and inhibition tasks. In this competing renewal, we will expand the baseline sample from 128 to 285 youth, and follow these adolescents quarterly with interviews on substance use and general functioning. Each subject who initiates heavy drinking (defined as consuming >5 drinks on an occasion >5 times in a month), as well as a non-user matched for age, gender, and family history status, will be invited back to repeat the protocol on an annual basis for the duration of the 5-year project. Based on surveys in the school districts we recruit from (A/=5420), we anticipate that >20% (n>50) will initiate heavy drinking and 50% (n>125) will remain non-users as of the 4-year follow-up (i.e., by age 16-18).
Aims : The goal of this study is to ascertain if indices of brain functioning (i.e., neuropsychological testing;hippocampal, prefrontal cortex, and cerebellar volumes;and FMRI response to spatial working memory and inhibition tasks in prefrontal and parietal regions) change after the onset of heavy drinking to a different degree than would be accounted for by normal adolescent neurodevelopment. We hypothesize that initiation of heavy drinking during adolescence will be associated with changes in brain structure and function, and that family history of AUD and gender will moderate this relationship. Other substance use (marijuana and nicotine) and other risk factors for SUD (externalizing behaviors, level of response to alcohol, and alcohol expectancies) will be evaluated as potential contributors to change in brain functioning. Based on our previous studies, we further hypothesize that baseline brain response patterns will significantly predict substance involvement in the following year.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA013419-09
Application #
7822963
Study Section
Neurotoxicology and Alcohol Study Section (NAL)
Program Officer
Witt, Ellen
Project Start
2002-02-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
9
Fiscal Year
2010
Total Cost
$492,331
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Nguyen-Louie, Tam T; Courtney, Kelly E; Squeglia, Lindsay M et al. (2017) Prospective changes in neural alcohol cue reactivity in at-risk adolescents. Brain Imaging Behav :
Nguyen-Louie, Tam T; Matt, Georg E; Jacobus, Joanna et al. (2017) Earlier Alcohol Use Onset Predicts Poorer Neuropsychological Functioning in Young Adults. Alcohol Clin Exp Res 41:2082-2092
Nguyen-Louie, Tam T; Brumback, Ty; Worley, Matthew J et al. (2017) Effects of sleep on substance use in adolescents: a longitudinal perspective. Addict Biol :
Courtney, Kelly E; Worley, Matthew; Castro, Norma et al. (2017) The effects of alcohol hangover on future drinking behavior and the development of alcohol problems. Addict Behav 78:209-215
Meruelo, A D; Castro, N; Cota, C I et al. (2017) Cannabis and alcohol use, and the developing brain. Behav Brain Res 325:44-50
Jacobus, Joanna; Squeglia, Lindsay M; Escobar, Silvia et al. (2017) Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users. Psychopharmacology (Berl) 234:3431-3442
Squeglia, Lindsay M; Ball, Tali M; Jacobus, Joanna et al. (2017) Neural Predictors of Initiating Alcohol Use During Adolescence. Am J Psychiatry 174:172-185
Brumback, T Y; Worley, Matthew; Nguyen-Louie, Tam T et al. (2016) Neural predictors of alcohol use and psychopathology symptoms in adolescents. Dev Psychopathol 28:1209-1216
Brumback, T; Castro, N; Jacobus, J et al. (2016) Effects of Marijuana Use on Brain Structure and Function: Neuroimaging Findings from a Neurodevelopmental Perspective. Int Rev Neurobiol 129:33-65
Jacobus, Joanna; Castro, Norma; Squeglia, Lindsay M et al. (2016) Adolescent cortical thickness pre- and post marijuana and alcohol initiation. Neurotoxicol Teratol 57:20-29

Showing the most recent 10 out of 97 publications