Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG026249-01
Application #
6949856
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J1))
Program Officer
Snyder, Stephen D
Project Start
2004-09-30
Project End
2009-08-31
Budget Start
2004-09-30
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$288,699
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Bennett, Rachel E; Robbins, Ashley B; Hu, Miwei et al. (2018) Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proc Natl Acad Sci U S A 115:E1289-E1298
DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin et al. (2018) Tau reduction in the presence of amyloid-? prevents tau pathology and neuronal death in vivo. Brain 141:2194-2212
Nobuhara, Chloe K; DeVos, Sarah L; Commins, Caitlin et al. (2017) Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol 187:1399-1412
Bennett, Rachel E; DeVos, Sarah L; Dujardin, Simon et al. (2017) Enhanced Tau Aggregation in the Presence of Amyloid ?. Am J Pathol 187:1601-1612
Takeda, Shuko; Commins, Caitlin; DeVos, Sarah L et al. (2016) Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol 80:355-67
Wegmann, Susanne; Nicholls, Samantha; Takeda, Shuko et al. (2016) Formation, release, and internalization of stable tau oligomers in cells. J Neurochem 139:1163-1174
Wegmann, Susanne; Maury, Eduardo A; Kirk, Molly J et al. (2015) Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J 34:3028-41
Takeda, Shuko; Wegmann, Susanne; Cho, Hansang et al. (2015) Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun 6:8490
Pooler, Amy M; Polydoro, Manuela; Maury, Eduardo A et al. (2015) Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathol Commun 3:14
Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose et al. (2014) Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett 562:63-8

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