We propose to examine the effects of executive control and fatigue on the maintenance of mobility and risk of mobility disability in older adults and their underlying brain substrates. Our overall working hypothesis is that mobility, executive control, and fatigue are closely linked through the frontal cortex-basal ganglia system in older adults. We propose to recruit 450 non- demented community-residing individuals age 70 years and older for baseline and annual follow-ups over the 5-year study period. Study measures will be administered in each yearly evaluation to identify cross-sectional and longitudinal effects of executive control and fatigue on mobility (aim 1). Functional Near Infrared Spectroscopy (FNIRS) will be used in each study visit to identify in motion PFC functional correlates of mobility (aim 2). Structural and functional MRI will be administered to a subsample (n=70) at baseline to augment our assessment of brain correlates of mobility.

Public Health Relevance

At present, cognitive function and fatigue are not routinely included in the risk assessment of mobility decline and disability in older adults. Furthermore, current mobility interventions do not specifically target cognitive function or fatigue. If successful, the findings of this proposal may substantially impact clinical practice guidelines. This proposal is designed to shed light on specific structural and functional brain substrates implicated in mobility. As such, we hope that our findings will further knowledge of causal and potentially modifiable predictors of mobility decline and disability in older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG036921-02
Application #
8232032
Study Section
Special Emphasis Panel (ZRG1-BDA-M (02))
Program Officer
Chen, Wen G
Project Start
2011-03-01
Project End
2016-02-29
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
2
Fiscal Year
2012
Total Cost
$660,491
Indirect Cost
$249,993
Name
Albert Einstein College of Medicine
Department
Neurology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Pillemer, Sarah C; Holtzer, Roee (2016) The differential relationships of dimensions of perceived social support with cognitive function among older adults. Aging Ment Health 20:727-35
Holtzer, Roee; Verghese, Joe; Allali, Gilles et al. (2016) Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis. Brain Topogr 29:334-43
Tow, Amanda; Holtzer, Roee; Wang, Cuiling et al. (2016) Cognitive Reserve and Postoperative Delirium in Older Adults. J Am Geriatr Soc 64:1341-6
Allali, Gilles; Ayers, Emmeline I; Verghese, Joe (2016) Motoric Cognitive Risk Syndrome Subtypes and Cognitive Profiles. J Gerontol A Biol Sci Med Sci 71:378-84
Allali, G; Annweiler, C; Blumen, H M et al. (2016) Gait phenotype from mild cognitive impairment to moderate dementia: results from the GOOD initiative. Eur J Neurol 23:527-41
Perice, Leland; Barzilai, Nir; Verghese, Joe et al. (2016) Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging (Albany NY) 8:2414-2424
Mahoney, Jeannette R; Holtzer, Roee; Izzetoglu, Meltem et al. (2016) The role of prefrontal cortex during postural control in Parkinsonian syndromes a functional near-infrared spectroscopy study. Brain Res 1633:126-38
Verghese, Joe (2016) Person-Centered Fall Risk Awareness Perspectives: Clinical Correlates and Fall Risk. J Am Geriatr Soc 64:2528-2532
England, Sarah E; Verghese, Joe; Mahoney, Jeannette R et al. (2015) Three-level rating of turns while walking. Gait Posture 41:300-3
Mahoney, Jeannette R; Dumas, Kristina; Holtzer, Roee (2015) Visual-Somatosensory Integration is Linked to Physical Activity Level in Older Adults. Multisens Res 28:11-29

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