We propose to examine the effects of executive control and fatigue on the maintenance of mobility and risk of mobility disability in older adults and their underlying brain substrates. Our overall working hypothesis is that mobility, executive control, and fatigue are closely linked through the frontal cortex-basal ganglia system in older adults. We propose to recruit 450 non- demented community-residing individuals age 70 years and older for baseline and annual follow-ups over the 5-year study period. Study measures will be administered in each yearly evaluation to identify cross-sectional and longitudinal effects of executive control and fatigue on mobility (aim 1). Functional Near Infrared Spectroscopy (FNIRS) will be used in each study visit to identify in motion PFC functional correlates of mobility (aim 2). Structural and functional MRI will be administered to a subsample (n=70) at baseline to augment our assessment of brain correlates of mobility.

Public Health Relevance

At present, cognitive function and fatigue are not routinely included in the risk assessment of mobility decline and disability in older adults. Furthermore, current mobility interventions do not specifically target cognitive function or fatigue. If successful, the findings of this proposal may substantially impact clinical practice guidelines. This proposal is designed to shed light on specific structural and functional brain substrates implicated in mobility. As such, we hope that our findings will further knowledge of causal and potentially modifiable predictors of mobility decline and disability in older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-BDA-M (02))
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Chen, Wen G
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Albert Einstein College of Medicine
Schools of Medicine
United States
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Mahoney, Jeannette R; Wang, Cuiling; Dumas, Kristina et al. (2014) Visual-somatosensory integration in aging: does stimulus location really matter? Vis Neurosci 31:275-83
Mahoney, Jeannette R; Holtzer, Roee; Verghese, Joe (2014) Visual-somatosensory integration and balance: evidence for psychophysical integrative differences in aging. Multisens Res 27:17-42
Li, Clara; Verghese, Joe; Holtzer, Roee (2014) A comparison of two walking while talking paradigms in aging. Gait Posture 40:415-9
Blumen, Helena M; Holtzer, Roee; Brown, Lucy L et al. (2014) Behavioral and neural correlates of imagined walking and walking-while-talking in the elderly. Hum Brain Mapp 35:4090-104
Shuman-Paretsky, Melissa J; Belser-Ehrlich, Janna; Holtzer, Roee (2014) Psychometric properties of the Brief Fatigue Inventory in community-dwelling older adults. Arch Phys Med Rehabil 95:1533-9
Allali, Gilles; Verghese, Joe; Mahoney, Jeannette R (2014) Contributions of mild parkinsonian signs to gait performance in the elderly. Age (Dordr) 36:9678
Holtzer, Roee; Epstein, Noah; Mahoney, Jeannette R et al. (2014) Neuroimaging of mobility in aging: a targeted review. J Gerontol A Biol Sci Med Sci 69:1375-88
Holtzer, Roee; Mahoney, Jeannette; Verghese, Joe (2014) Intraindividual variability in executive functions but not speed of processing or conflict resolution predicts performance differences in gait speed in older adults. J Gerontol A Biol Sci Med Sci 69:980-6
Verghese, Joe; Annweiler, Cedric; Ayers, Emmeline et al. (2014) Motoric cognitive risk syndrome: multicountry prevalence and dementia risk. Neurology 83:718-26
Holtzer, Roee; Wang, Cuiling; Verghese, Joe (2014) Performance variance on walking while talking tasks: theory, findings, and clinical implications. Age (Dordr) 36:373-81

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