This research will advance our understanding of osteoporosis. Osteoporosis is a disease in which bones become fragile and more likely to break. If not prevented or if left untreated, osteoporosis can progress painlessly until a bone fractures. It is a major public health threat for an estimated 44 million Americans. In particular, osteoporotic fractures of the proximal femur are the most common and often result in high rates of morbidity and mortality. An average of 24 percent of hip fracture patients aged 50 and over die in the year following their fracture. This represents a serious socioeconomic health problem that is expected to worsen as the size of the elderly population increases. Numerous publications have demonstrated that bone mineral density alone cannot entirely differentiate between osteoporotic and healthy subjects and that the structural make-up of trabecular bone provides additional information to assess the risk of fracture. Imaging of the proximal femur has not yet been performed in vivo with high resolution. In MRI, this is mainly due to signal to noise issues and a lack of dedicated imaging coils. With the proposed technique, in vivo 3D-images of the entire proximal femur with sufficient high spatial resolution to visualize the trabecular microstructure will be acquired. Structural parameters of the trabecular bone will be derived from these images. These parameters have been shown to be well suited for predicting hip fracture. Through early detection, the progression and response to therapy can be monitored more sensitively, and the risk of hip fracture effectively ascertained. The proposed study will provide the first assessment of trabecular bone microstructure in the proximal femur. The results of the proposed research may also influence treatment strategies.

Public Health Relevance

This research will advance our understanding of osteoporosis. Osteoporosis is a disease in which bones become fragile and more likely to break. If not prevented or if left untreated, osteoporosis can progress painlessly until a bone breaks. It is a major public health threat for an estimated 44 million Americans. In particular, osteoporotic fractures of the proximal femur are the most common and often result in high rates of morbidity and mortality. An average of 24 percent of hip fracture patients aged 50 and over die in the year following their fracture. This represents a serious socioeconomic health problem that is expected to worsen as the size of the elderly population increases. With the proposed technique, 3-D images of the proximal femur in vivo with sufficient spatial resolution will be acquired for the first time. Structural bone parameters derived from these enhanced images are suited to predict hip fracture. Through early detection, the progression and response to therapy can be monitored more sensitively, and the risk of hip fracture effectively ascertained. The proposed study will provide the first assessment of trabecular bone microstructure in the proximal femur. The results of the proposed research may also influence treatment strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR057336-02
Application #
7921957
Study Section
Skeletal Biology Development and Disease Study Section (SBDD)
Program Officer
Lester, Gayle E
Project Start
2009-09-01
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$340,343
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Karampinos, Dimitrios C; Ruschke, Stefan; Dieckmeyer, Michael et al. (2018) Quantitative MRI and spectroscopy of bone marrow. J Magn Reson Imaging 47:332-353
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Han, Misung; Chiba, Ko; Banerjee, Suchandrima et al. (2015) Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging 41:1300-10
Nardo, Lorenzo; Karampinos, Dimitrios C; Lansdown, Drew A et al. (2014) Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI. J Magn Reson Imaging 39:1178-85
Karampinos, Dimitrios C; Melkus, Gerd; Baum, Thomas et al. (2014) Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS. Magn Reson Med 71:1158-65

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