The overall objective of this research is to improve our understanding of why adolescents start to use tobacco, alcohol, marijuana and other drugs, both over the counter (OTC) and illicit, and why some subsequently become problem users and abusers. The specific objectives and aims are as follows: 1) Collect two more waves of predictor and drug use data, at grade 11 and two years later, from a cohort of Southern California students on whom we already have up to three waves (grades 7-9 of self-report, parent, and school personnel data (N=4450). An additional 4000 students will be surveyed at grade 11; a sample of 1250 of these students who score the highest on a multivariate risk factor will also be followed two years later. The grade 11 will be collected in Southern California high schools by USC staff during year 01, and the final wave of data will be collected by mail or phone by the UIC Survey Research Lab in the spring of 1992 (year 03 of the grant). 2) Investigate the role of family variables and adolescent mental health in the onset of drug abuse. This work will be conducted mostly at USC.
Specific aims regarding this objective include assessing the importance of latchkey status as a predictor of drug abuse in a multivariate context, investigating the relationship between latchkey status and other indicators of conventional social bonding, and examining the relationship between latchkey status and depression and their prediction of drug use. 3) Compare the goodness of fit of alternative explanatory theories of the onset of drug use and abuse. This work will be conducted at UIC.
The specific aims within this objective include assessing the robustness and stability of junior high school student and parent predictors thorough post high school, comparing the goodness of fit of several alternative predictive theories of drug use and abuse, examining the relationships between micro- and macro-level predictors from various theories, and developing and testing the goodness of fit of an """"""""optimum"""""""" integrated model. The proposed study is important because it: encompasses the high risk age range (12-18); includes data from parents (grade 7-9) and schools (grades 7-9 & 11); enables tests and contrasts of the most important of the existing theories; incorporates a wider range of variables than any other single study; includes data from an ethnically and socioeconomically diverse population; includes five waves of data; utilizes sophisticated analytical techniques to examine interactions and mediating relationships and to contrast models; has a large enough sample size to enable split-half testing and replication for all analyses; will have important implications for future prevention programs/research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006307-02
Application #
3212963
Study Section
Drug Abuse Epidemiology and Prevention Research Review Committee (DAPA)
Project Start
1991-02-01
Project End
1995-01-31
Budget Start
1992-02-01
Budget End
1993-01-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Type
Schools of Public Health
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Hedeker, D; Siddiqui, O; Hu, F B (2000) Random-effects regression analysis of correlated grouped-time survival data. Stat Methods Med Res 9:161-79
Siddiqui, O; Mott, J; Anderson, T et al. (1999) The application of Poisson random-effects regression models to the analyses of adolescents' current level of smoking. Prev Med 29:92-101
Siddiqui, O; Mott, J A; Anderson, T L et al. (1999) Characteristics of inconsistent respondents who have ""ever used"" drugs in a school-based sample. Subst Use Misuse 34:269-95
Petraitis, J; Flay, B R; Miller, T Q et al. (1998) Illicit substance use among adolescents: a matrix of prospective predictors. Subst Use Misuse 33:2561-604
Flay, B R; Hu, F B; Richardson, J (1998) Psychosocial predictors of different stages of cigarette smoking among high school students. Prev Med 27:A9-18
Hu, F B; Hedeker, D; Day, L E et al. (1997) Patterns of use of smokeless tobacco and the unidimensional model of drug involvement. Addict Behav 22:257-61
Hu, F B; Persky, V; Flay, B R et al. (1997) An epidemiological study of asthma prevalence and related factors among young adults. J Asthma 34:67-76
Hedeker, D; Flay, B R; Petraitis, J (1996) Estimating individual influences of behavioral intentions: an application of random-effects modeling to the theory of reasoned action. J Consult Clin Psychol 64:109-20
Siddiqui, O; Hedeker, D; Flay, B R et al. (1996) Intraclass correlation estimates in a school-based smoking prevention study. Outcome and mediating variables, by sex and ethnicity. Am J Epidemiol 144:425-33
Siddiqui, O; Flay, B R; Hu, F B (1996) Factors affecting attrition in a longitudinal smoking prevention study. Prev Med 25:554-60

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