Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA070097-02
Application #
2114050
Study Section
Pathology B Study Section (PTHB)
Project Start
1995-08-28
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Hilgers, W; Song, J J; Haye, M et al. (2000) Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers. Genes Chromosomes Cancer 27:353-7
Kolligs, F T; Kolligs, B; Hajra, K M et al. (2000) gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev 14:1319-31
Meyerhardt, J A; Caca, K; Eckstrand, B C et al. (1999) Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ 10:35-42
Rimm, D L; Caca, K; Hu, G et al. (1999) Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 154:325-9
Caca, K; Kolligs, F T; Ji, X et al. (1999) Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. Cell Growth Differ 10:369-76
Hajra, K M; Ji, X; Fearon, E R (1999) Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene 18:7274-9
Kolligs, F T; Hu, G; Dang, C V et al. (1999) Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol Cell Biol 19:5696-706
Hu, G; Fearon, E R (1999) Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol Cell Biol 19:724-32
Meyerhardt, J A; Look, A T; Bigner, S H et al. (1997) Identification and characterization of neogenin, a DCC-related gene. Oncogene 14:1129-36
Reyes-Mugica, M; Rieger-Christ, K; Ohgaki, H et al. (1997) Loss of DCC expression and glioma progression. Cancer Res 57:382-6

Showing the most recent 10 out of 13 publications