The research proposed in this application aims to understand genetic and environmental factors that promote desistance or continuation of problematic substance use and associated high-risk behaviors that began in adolescence. We propose an ~12-year follow-up (6 years after an initial 6-year follow-up) of an extremely affected adolescent sample as they transition into adulthood; this is a critical developmental period when we expect a portion of these individuals to decrease or desist problematic substance use and associated high-risk behaviors, while others will persist with the most serious, destructive behaviors leading to devastatingly high rates of morbidity and mortality. Our central goal is to understand the genetic and environmental factors that delineate these life trajectories. Results from our longitudinal research demonstrate that adolescent-onset substance users, who primarily exhibited abuse of and dependence on marijuana, nicotine, and alcohol during adolescence, progressed in the severity of their substance use five years later. As young adults, they report dramatically high rates of lifetime cocaine (29.2%), amphetamine (29.2%), and opiate (10.8%) use disorders as well as HIV/AIDS-related risk behaviors such as injection drug use (11%) and risky sexual behaviors. Indeed, when compared with community samples, these individuals report more than twice the number of lifetime sexual partners and a 33% higher rate of unprotected sex. Furthermore, they exhibit alarming rates of adult incarceration (55%) and early death (2.6%). This proposal extends our multiple-PI collaboration focused on the genetic epidemiology of adolescent-onset drug dependence. The three specific aims are to: 1) Identify distinct developmental trajectories of substance use, antisocial, and HIV risk behaviors in probands and siblings from adolescence to adulthood. a) Test initial characteristics of the adolescents, such as sex, severity of early onset substance use disorders (SUDs) and conduct disorder (CD), and neurocognitive functioning (e.g., disinhibition) that predict these trajectories and b) Test whether adult resources such as treatment for SUDs, housing stability, occupational stability, and social support are associated with these trajectories. 2) Determine the genetic and environmental architecture of developmental trajectories of substance use disorders, antisocial and HIV risk behaviors. a) Test the moderating role of social context, such as SES, criminal justice involvement, substance abuse treatment/self-help involvement, and stressful life events, in altering genetic influence and b) Test whether moderating effects vary across developmental periods (adolescence, young adulthood, and adulthood). 3) Test the influence of shared versus specific etiologic influences on measures of SUDs, antisocial behaviors, and HIV risk behaviors across development.

Public Health Relevance

Adolescent onset substance use problems present a serious public health problem. Youth who exhibit drug and alcohol problems are at high risk for persisting with these behaviors as they become adults and many develop more serious addictions, including cocaine, methamphetamine, and opiate addictions. This study will follow the largest sample of youth who presented with adolescent onset substance problems into adulthood. It will examine factors that predict persisting versus desisting with drug and alcohol problems, as well as HIV risk behaviors and antisocial behaviors. Because the study also recruits siblings of youth with substance problems and is linked with a larger community sample of twins and adoptees, it will be able to explore genetic and environmental influences on problem behaviors.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Weinberg, Naimah Z
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University of Colorado Denver
Schools of Medicine
United States
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Gustavson, Daniel E; Stallings, Michael C; Corley, Robin P et al. (2017) Executive functions and substance use: Relations in late adolescence and early adulthood. J Abnorm Psychol 126:257-270
Kim, Janet; Coors, Marilyn E; Young, Susan E et al. (2017) Cannabis use disorder and male sex predict medical cannabis card status in a sample of high risk adolescents. Drug Alcohol Depend 183:25-33
Luczak, Susan E; Liang, Tiebing; Wall, Tamara L (2017) Age of Drinking Initiation as a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity. Alcohol Clin Exp Res 41:1738-1744
Klawitter, Jelena; Sempio, Cristina; Mörlein, Sophie et al. (2017) An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit 39:556-564
Al-Tayyib, Alia; Riggs, Paula; Mikulich-Gilbertson, Susan et al. (2017) Prevalence of Nonmedical Use of Prescription Opioids and Association With Co-occurring Substance Use Disorders Among Adolescents in Substance Use Treatment. J Adolesc Health :
Luk, Jeremy W; Trim, Ryan S; Karyadi, Kenny A et al. (2017) Unique and interactive effects of impulsivity facets on reckless driving and driving under the influence in a high-risk young adult sample. Pers Individ Dif 114:42-47
Wills, Amanda G; Evans, Luke M; Hopfer, Christian (2017) Phenotypic and Genetic Relationship Between BMI and Drinking in a Sample of UK Adults. Behav Genet 47:290-297
Benca, Chelsie E; Derringer, Jaime L; Corley, Robin P et al. (2017) Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders. Behav Genet 47:11-24
Luk, Jeremy W; Worley, Matthew J; Winiger, Evan et al. (2016) Risky driving and sexual behaviors as developmental outcomes of co-occurring substance use and antisocial behavior. Drug Alcohol Depend 169:19-25
Haberstick, Brett C; Boardman, Jason D; Wagner, Brandon et al. (2016) Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). PLoS One 11:e0148373

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