Bone loss is a major, frequent and often permanent comorbid medical complication of anorexia nervosa (AN) affecting over half of all women with this disease and resulting in debilitating fractures, yet there are few effective therapies. In this proposal, we will test the effectiveness of a sequential therapeutic regimen designed to specifically: 1) reverse insulin-like growth factor 1 deficiency, thereby stimulating bone formation, and 2) reduce bone breakdown, using a bisphosphonate, a medication that is effective at reversing bone loss.

Public Health Relevance

Anorexia nervosa affects from 0.5-1.0% of college-age women and is complicated by severe bone loss, with a reduction of bone mineral density (BMD) by at least 1.0 SD in over 90% and by at least 2.5 SD in over one- third of patients. Moreover, anorexia nervosa is associated with a 30% prevalence of fractures. Effective therapies for this complication are needed. This proposal addresses this important public health problem with a randomized, placebo-controlled study of promising therapies for bone loss in this population, which is resistant to traditional approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052625-13
Application #
8516010
Study Section
Skeletal Biology Structure and Regeneration Study Section (SBSR)
Program Officer
Malozowski, Saul N
Project Start
1997-05-19
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
13
Fiscal Year
2013
Total Cost
$629,351
Indirect Cost
$269,874
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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