This proposal aims to develop a stretchable and flexible sensor technology capable of transforming healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, and person-centered. The goal is to offer 'skin-like'properties, to enable intimate, complete non-invasive integration with the patient. The resulting 'epidermal'electronic devices may allow clinicians to monitor their patients, and the general public to assess, continuously, their health and well-being. The proposed interface monitoring system, designed to promote residual limb health in persons who wear prostheses, in physical forms that are 'skin like', may demonstrate key technological and scientific advancements towards evidenced-based and person-centered prosthetic care. The work involves """""""" Development of 'skin-like'pressure, strain and temperature sensors, with wireless operation, as well as hydration and blood flow sensors. """""""" Development of computational modeling and algorithms for statistical signal processing of the sensor data and pattern recognition to create a user-friendly interface for clinicians and patients. """""""" Application of the proposed sensor technologies and data processing and pattern recognition techniques to prosthetic clinical practice. The continuous capture, storage and transmission of sensor data are critical to the design of lower limb prosthetics for improved health and healthcare. The proposed work is consonant with the mission of NIBIB to improve health by leading development of new biomedical imaging devices for early detection and prevention of health problems and assessment of health status. In addition to prosthetic care, the proposal may address an unmet need for a model system for individualized healthcare, in which continuous sensing, monitoring and assessment are performed using wireless epidermal sensors instead of traditional lab-based instrumentation.

Public Health Relevance

The proposed interface monitoring system, designed to promote residual limb health in persons who wear prostheses, in physical forms that are 'skin like', may demonstrate key technological and scientific advancements towards evidenced-based and person-centered prosthetic care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB019337-01
Application #
8788318
Study Section
Special Emphasis Panel ()
Program Officer
Peng, Grace
Project Start
2014-09-22
Project End
2018-05-31
Budget Start
2014-09-22
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$410,930
Indirect Cost
$83,998
Name
Northwestern University at Chicago
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
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Yan, Zheng; Zhang, Fan; Wang, Jiechen et al. (2016) Controlled mechanical buckling for origami-inspired construction of 3D microstructures in advanced materials. Adv Funct Mater 26:2629-2639
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Liu, Yuan; Yan, Zheng; Lin, Qing et al. (2016) Guided Formation of 3D Helical Mesostructures by Mechanical Buckling: Analytical Modeling and Experimental Validation. Adv Funct Mater 26:2909-2918
Kim, Jeonghyun; Salvatore, Giovanni A; Araki, Hitoshi et al. (2016) Battery-free, stretchable optoelectronic systems for wireless optical characterization of the skin. Sci Adv 2:e1600418

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