This proposal aims to develop a stretchable and flexible sensor technology capable of transforming healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, and person-centered. The goal is to offer 'skin-like' properties, to enable intimate, complete non-invasive integration with the patient. The resulting 'epidermal' electronic devices may allow clinicians to monitor their patients, and the general public to assess, continuously, their health and well-being. The proposed interface monitoring system, designed to promote residual limb health in persons who wear prostheses, in physical forms that are 'skin like', may demonstrate key technological and scientific advancements towards evidenced-based and person-centered prosthetic care. The work involves Development of 'skin-like' pressure, strain and temperature sensors, with wireless operation, as well as hydration and blood flow sensors. Development of computational modeling and algorithms for statistical signal processing of the sensor data and pattern recognition to create a user-friendly interface for clinicians and patients. Application of the proposed sensor technologies and data processing and pattern recognition techniques to prosthetic clinical practice. The continuous capture, storage and transmission of sensor data are critical to the design of lower limb prosthetics for improved health and healthcare. The proposed work is consonant with the mission of NIBIB to improve health by leading development of new biomedical imaging devices for early detection and prevention of health problems and assessment of health status. In addition to prosthetic care, the proposal may address an unmet need for a model system for individualized healthcare, in which continuous sensing, monitoring and assessment are performed using wireless epidermal sensors instead of traditional lab-based instrumentation.

Public Health Relevance

The proposed interface monitoring system, designed to promote residual limb health in persons who wear prostheses, in physical forms that are 'skin like', may demonstrate key technological and scientific advancements towards evidenced-based and person-centered prosthetic care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB019337-04
Application #
9313641
Study Section
Special Emphasis Panel (ZRG1-HDM-Y (07))
Program Officer
Wolfson, Michael
Project Start
2014-09-22
Project End
2018-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
4
Fiscal Year
2017
Total Cost
$347,904
Indirect Cost
$52,049
Name
Northwestern University at Chicago
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wang, Heling; Ning, Xin; Li, Haibo et al. (2018) Vibration of Mechanically-Assembled 3D Microstructures Formed by Compressive Buckling. J Mech Phys Solids 112:187-208
Ning, Xin; Yu, Xinge; Wang, Heling et al. (2018) Mechanically active materials in three-dimensional mesostructures. Sci Adv 4:eaat8313
Fu, Haoran; Nan, Kewang; Bai, Wubin et al. (2018) Morphable 3D mesostructures and microelectronic devices by multistable buckling mechanics. Nat Mater 17:268-276
Tran, Lilly; Caldwell, Ryan; Quigley, Matthew et al. (2018) Stakeholder perspectives for possible residual limb monitoring system for persons with lower-limb amputation. Disabil Rehabil :1-8
Bai, Wubin; Yang, Hongjun; Ma, Yinji et al. (2018) Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon. Adv Mater 30:e1801584
Chen, Hang; Zhu, Feng; Jang, Kyung-In et al. (2018) The equivalent medium of cellular substrate under large stretching, with applications to stretchable electronics. J Mech Phys Solids 120:199-207
Han, Seungyong; Kim, Jeonghyun; Won, Sang Min et al. (2018) Battery-free, wireless sensors for full-body pressure and temperature mapping. Sci Transl Med 10:
Kim, Bong Hoon; Lee, Jungyup; Won, Sang Min et al. (2018) Three-Dimensional Silicon Electronic Systems Fabricated by Compressive Buckling Process. ACS Nano 12:4164-4171
Ning, Xin; Wang, Heling; Yu, Xinge et al. (2017) Three-Dimensional Multiscale, Multistable, and Geometrically Diverse Microstructures with Tunable Vibrational Dynamics Assembled by Compressive Buckling. Adv Funct Mater 27:
Xu, Renxiao; Lee, Jung Woo; Pan, Taisong et al. (2017) Designing Thin, Ultrastretchable Electronics with Stacked Circuits and Elastomeric Encapsulation Materials. Adv Funct Mater 27:

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