Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES007572-02
Application #
2157008
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1995-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
Organized Research Units
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Bocangel, Dora; Sengupta, Shiladitya; Mitra, Sankar et al. (2009) p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor. Anticancer Res 29:3741-50
Mitra, Sankar (2007) MGMT: a personal perspective. DNA Repair (Amst) 6:1064-70
Bhakat, Kishor K; Mitra, Sankar (2003) CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. Carcinogenesis 24:1337-45
Biswas, Tapan; Clos 2nd, Lawrence J; SantaLucia Jr, John et al. (2002) Binding of specific DNA base-pair mismatches by N-methylpurine-DNA glycosylase and its implication in initial damage recognition. J Mol Biol 320:503-13
Bhakat, K K; Mitra, S (2000) Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300. J Biol Chem 275:34197-204
Roy, G; Horton, J K; Roy, R et al. (2000) Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins. Oncogene 19:141-50
Horton, J K; Roy, G; Piper, J T et al. (1999) Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu. Biochem Pharmacol 58:693-702
Biswas, T; Ramana, C V; Srinivasan, G et al. (1999) Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone. Oncogene 18:525-32
Boldogh, I; Ramana, C V; Chen, Z et al. (1998) Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling. Cancer Res 58:3950-6
Bhattacharyya, D; Hazra, T K; Behnke, W D et al. (1998) Reversible folding of Ada protein (O6-methylguanine-DNA methyltransferase) of Escherichia coli. Biochemistry 37:1722-30

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