Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002061-19
Application #
2158335
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1978-02-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Zhu, DanHong; Sreekumar, Parameswaran G; Hinton, David R et al. (2010) Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res 50:643-51
He, Shikun; Kumar, S Ram; Zhou, Peng et al. (2010) Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci 51:543-52
Sreekumar, Parameswaran G; Ding, Yi; Ryan, Stephen J et al. (2009) Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Exp Eye Res 88:410-7
He, Shikun; Chen, Youxin; Khankan, Rima et al. (2008) Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci 49:4078-88
Yaung, Jennifer; Kannan, Ram; Wawrousek, Eric F et al. (2008) Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res 86:355-65
Yaung, Jennifer; Jin, Manlin; Barron, Ernesto et al. (2007) alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis 13:566-77
Gamulescu, Maria-Andreea; Chen, Youxin; He, Shikun et al. (2006) Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res 83:212-22
Sreekumar, Parameswaran G; Kannan, Ram; Yaung, Jennifer et al. (2005) Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun 334:245-53
Jin, Manlin; Yaung, Jennifer; Kannan, Ram et al. (2005) Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci 46:4311-9
Hoffmann, Stephan; He, Shikun; Jin, Manlin et al. (2005) A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol 5:16

Showing the most recent 10 out of 61 publications