The postnatal development of both the optical and neural visual systems is dependent on visual experience. Visual experience can be defined by the information available in the retinal images in the two eyes. The goal of the proposed research is to understand how the visual system controls this visual experience with accommodation and vergence motor responses, in normal development, amblyopia and strabismus. There are four interrelated projects: i) To understand motor performance over extended periods of time, to test hypotheses related to current theories of the effects of integrated experience on activity-dependent processes. ii) To determine the cues used in generating accommodation and vergence motor responses during development, to test hypotheses related to cue redundancy and the development of strabismus and amblyopia. iii) To determine the role of accommodation and vergence in the management of strabismus and test hypotheses about the control of these motor responses after surgery. iv) To understand retinal visual experience during amblyopia therapy and its role in successful treatments.

Public Health Relevance

Normal development of both the optical and neural visual systems is dependent on visual experience. Visual experience can be defined by the information available in the images formed on the retina. The goal of the proposed research is to understand how the accommodation and vergence responses of infants and young children impact their visual experience and the role that these responses play in normal and abnormal development, specifically in the context of amblyopia and strabismus.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY014460-11
Application #
8651493
Study Section
(SPC)
Program Officer
Araj, Houmam H
Project Start
2002-12-01
Project End
2017-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Indiana University Bloomington
Department
Type
Schools of Optometry/Opht Tech
DUNS #
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Sreenivasan, Vidhyapriya; Babinsky, Erin E; Wu, Yifei et al. (2016) Objective Measurement of Fusional Vergence Ranges and Heterophoria in Infants and Preschool Children. Invest Ophthalmol Vis Sci 57:2678-88
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2016) Vergence Adaptation to Short-Duration Stimuli in Early Childhood. Invest Ophthalmol Vis Sci 57:920-7
Seemiller, Eric S; Wang, Jingyun; Candy, T Rowan (2016) Sensitivity of vergence responses of 5- to 10-week-old human infants. J Vis 16:20
Babinsky, Erin; Sreenivasan, Vidhyapriya; Candy, T Rowan (2015) Near heterophoria in early childhood. Invest Ophthalmol Vis Sci 56:1406-15
Manh, Vivian; Chen, Angela M; Tarczy-Hornoch, Kristina et al. (2015) Accommodative performance of children with unilateral amblyopia. Invest Ophthalmol Vis Sci 56:1193-207
Barrett, Brendan T; Bradley, Arthur; Candy, T Rowan (2013) The relationship between anisometropia and amblyopia. Prog Retin Eye Res 36:120-58
Bharadwaj, Shrikant R; Sravani, N Geetha; Little, Julie-Anne et al. (2013) Empirical variability in the calibration of slope-based eccentric photorefraction. J Opt Soc Am A Opt Image Sci Vis 30:923-31
Babinsky, Erin; Candy, T Rowan (2013) Why do only some hyperopes become strabismic? Invest Ophthalmol Vis Sci 54:4941-55
Candy, T Rowan; Gray, Kathryn H; Hohenbary, Christy C et al. (2012) The accommodative lag of the young hyperopic patient. Invest Ophthalmol Vis Sci 53:143-9
Candy, T Rowan (2012) Which hyperopic patients are destined for trouble? J AAPOS 16:107-9

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