This is the second resubmission application for a Clinical and Translational Science Award. We describe Penn State University's plan to transform our health research and education enterprise through the work of the Penn State Clinical and Translational Science Institute (CTSI). Throughout the University, the CTSI initiative has been greeted with great enthusiasm, broad support across colleges and campuses, and reaffirmation of our responsibility as a land grant University. The overarching goal of the Penn State CTSI is an engaged and responsive health science research and education enterprise that delivers on the promise of improved health. Starting with unique strengths in relevant biological, social and physical sciences, a culture and organizational structure that encourages collaboration across units, a tradition of engaging in problem-driven research, and strong connections to communities throughout Pennsylvania, we plan to achieve this by: 1) bolstering community alliances to strengthen trust, enhance awareness of disparities and ascertain needs;2) cultivating new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry;3) sharing resources and promoting their most proficient use;4) capitalizing on novel tools in information technology to collect, share and mine data, anci disseminate new knowledge;and 5) educating a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Penn State has a rich track record of breaking down barriers and of strong support for interdisciplinary collaboration, and has committed major resources to the CTSI. In this amended application, a new leadership team in biomedical informatics has been empowered to expand infrastructure and develop new software solutions to study genetics, epigenetics and systems biology. The University has increased its already substantial health science investment in transformational technologies, innovative educational programs, and major interdisciplinary pilot project programs. Jointly with our community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, preempt and treat disease in the people we serve.

Public Health Relevance

; This proposal describes the newly created Penn State Clinical and Translational Science Institute (CTSI). The overarching goal of our CTSI initiative is to revitalize the health science research and education enterprise at our University to better enable it to deliver on the promise of improved health.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Boller, Francois
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Pennsylvania State University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Chen, Allshine; Krebs, Nicolle M; Zhu, Junjia et al. (2018) Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study. Drug Alcohol Depend 190:89-93
Lewis, Mechelle M; Du, Guangwei; Baccon, Jennifer et al. (2018) Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes. Mov Disord 33:1432-1439
Du, Guangwei; Lewis, Mechelle M; Sica, Christopher et al. (2018) Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients. Mov Disord 33:1423-1431
Greenwood, Eleni A; Pasch, Lauri A; Cedars, Marcelle I et al. (2018) Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertil Steril 110:27-34
Calhoun, Brian H; Maggs, Jennifer L; Loken, Eric (2018) Change in college students' perceived parental permissibility of alcohol use and its relation to college drinking. Addict Behav 76:275-280
Stennett, Andrea; Krebs, Nicolle M; Liao, Jason et al. (2018) Ecological momentary assessment of smoking behaviors in native and converted intermittent smokers. Am J Addict 27:131-138
Sahlin, Kristoffer; Tomaszkiewicz, Marta; Makova, Kateryna D et al. (2018) Deciphering highly similar multigene family transcripts from Iso-Seq data with IsoCon. Nat Commun 9:4601
Streeper, Necole M; Lehman, Kathleen; Conroy, David E (2018) Acceptability of Mobile Health Technology for Promoting Fluid Consumption in Patients With Nephrolithiasis. Urology 122:64-69
Craig, Sarah J C; Blankenberg, Daniel; Parodi, Alice Carla Luisa et al. (2018) Child Weight Gain Trajectories Linked To Oral Microbiota Composition. Sci Rep 8:14030
Hobkirk, Andréa L; Krebs, Nicolle M; Muscat, Joshua E (2018) Income as a moderator of psychological stress and nicotine dependence among adult smokers. Addict Behav 84:215-223

Showing the most recent 10 out of 431 publications