Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL044575-06A2
Application #
2028525
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-07-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Annis, D S; Murphy-Ullrich, J E; Mosher, D F (2006) Function-blocking antithrombospondin-1 monoclonal antibodies. J Thromb Haemost 4:459-68
Orr, Anthony Wayne; Pallero, Manuel Antonio; Xiong, Wen-Cheng et al. (2004) Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J Biol Chem 279:48983-92
Elzie, Carrie Ann; Murphy-Ullrich, Joanne E (2004) The N-terminus of thrombospondin: the domain stands apart. Int J Biochem Cell Biol 36:1090-101
Orr, A Wayne; Murphy-Ullrich, Joanne E (2004) Regulation of endothelial cell function BY FAK and PYK2. Front Biosci 9:1254-66
Kevil, Christopher G; Orr, A Wayne; Langston, Will et al. (2004) Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway. J Biol Chem 279:19230-8
Orr, A Wayne; Elzie, Carrie A; Kucik, Dennis F et al. (2003) Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci 116:2917-27
Orr, Anthony Wayne; Pedraza, Claudio E; Pallero, Manuel Antonio et al. (2003) Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly. J Cell Biol 161:1179-89
Orr, Anthony Wayne; Pallero, Manuel Antonio; Murphy-Ullrich, Joanne E (2002) Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation. J Biol Chem 277:20453-60
Goicoechea, Silvia; Pallero, Manuel Antonio; Eggleton, Paul et al. (2002) The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem 277:37219-28
Murphy-Ullrich, J E (2001) The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state? J Clin Invest 107:785-90

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