Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048261-12
Application #
6691009
Study Section
Special Emphasis Panel (ZRG1-SSS-3 (03))
Program Officer
Croxton, Thomas
Project Start
1993-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
12
Fiscal Year
2004
Total Cost
$340,875
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Tang, Chi-Hui; Lee, Je-Wook; Galvez, Michael G et al. (2006) Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol 26:2309-16
Shi, G-P; Sukhova, G K; Kuzuya, M et al. (2003) Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res 92:493-500
Riese, R J; Chapman, H A (2000) Cathepsins and compartmentalization in antigen presentation. Curr Opin Immunol 12:107-13
Wolters, P J; Chapman, H A (2000) Importance of lysosomal cysteine proteases in lung disease. Respir Res 1:170-7
Villadangos, J A; Bryant, R A; Deussing, J et al. (1999) Proteases involved in MHC class II antigen presentation. Immunol Rev 172:109-20
Shi, G P; Sukhova, G K; Grubb, A et al. (1999) Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 104:1191-7
Driessen, C; Bryant, R A; Lennon-Dumenil, A M et al. (1999) Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol 147:775-90
Chapman, H A (1998) Endosomal proteolysis and MHC class II function. Curr Opin Immunol 10:93-102
Riese, R J; Mitchell, R N; Villadangos, J A et al. (1998) Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest 101:2351-63
Sukhova, G K; Shi, G P; Simon, D I et al. (1998) Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 102:576-83

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