The objective of this proposal is to develop a percutaneous respiratory assist catheter (PRAC) that can be inserted into the venous system to provide supplemental breathing support, independent of the lungs, for patients requiring short- term (less than 1-2 weeks) respiratory assistance. The PRAC will be designed for percutaneous insertion into a peripheral vein and placement in the central venous system, where it will be exposed to all the blood returning to the heart. The PRAC will incorporate a cylindrical bundle of microporous hollow fiber membranes woven as a fabric that is wrapped around a balloon. The balloon is pulsed with helium and enhances gas exchange by pumping blood past the hollow fibers at velocities much greater than would otherwise exist in the vena cava.
The specific aims of the project are to: 1. Fabricate candidate PRAC devices with insertional diameters of 25-28 Fr (8-9 mm) and evaluate the functional mass transfer characteristics in an in-vitro test loop. We will establish how the gas exchange performance of the PRAC depends on key operating and design parameters. 2. Evaluate and optimize balloon pulsation in the PRAC to improve gas exchange. We will principally explore changes in balloon geometry and balloon pulsation mode, and we will use flow visualization, local gas tension measurements, and computational simulations to help guide our design development. 3. Perform acute calf implants of the PRAC to assess the gas exchange functionality in-situ and any adverse anatomical, physiological and biocompatibility effects associated with short- term implantation. We will also evaluate the hemolysis potential of candidate PRAC designs in-vitro using bovine blood in a bench flow loop. Our target is a percutaneous assist catheter that can provide 75- 85 ml/min of extrapulmonary CO2 removal at normocapnia and that could be used as an adjuvant or replacement to existing therapy for patients with acute lung failure (ARDS, pneumonia) or acute on chronic lung failure (COPD with exacerbation).

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL070051-02
Application #
6608105
Study Section
Surgery and Bioengineering Study Section (SB)
Program Officer
Harabin, Andrea L
Project Start
2002-04-01
Project End
2006-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
2
Fiscal Year
2003
Total Cost
$401,567
Indirect Cost
Name
University of Pittsburgh
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Arazawa, D T; Kimmel, J D; Finn, M C et al. (2015) Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood. Acta Biomater 25:143-9
Arazawa, D T; Kimmel, J D; Federspiel, W J (2015) Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs. J Mater Sci Mater Med 26:193
Jeffries, R Garrett; Frankowski, Brian J; Burgreen, Greg W et al. (2014) Effect of impeller design and spacing on gas exchange in a percutaneous respiratory assist catheter. Artif Organs 38:1007-17
Kimmel, J D; Arazawa, D T; Ye, S-H et al. (2013) Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications. J Mater Sci Mater Med 24:2611-21
Arazawa, David T; Oh, Heung-Il; Ye, Sang-Ho et al. (2012) Immobilized Carbonic Anhydrase on Hollow Fiber Membranes Accelerates CO(2) Removal from Blood. J Memb Sci 404-404:25-31
Pacella, Heather E; Eash, Heidi J; Federspiel, William J (2011) Darcy Permeability of Hollow Fiber Bundles Used in Blood Oxygenation Devices. J Memb Sci 382:238-242
Oh, Heung-Il; Ye, Sang-Ho; Johnson Jr, Carl A et al. (2010) Hemocompatibility assessment of carbonic anhydrase modified hollow fiber membranes for artificial lungs. Artif Organs 34:439-42
Budilarto, Stephanus G; Frankowski, Brian J; Hattler, Brack G et al. (2009) Flow visualization study of a novel respiratory assist catheter. Artif Organs 33:411-8
Mihelc, Kevin M; Frankowski, Brian J; Lieber, Samuel C et al. (2009) Evaluation of a respiratory assist catheter that uses an impeller within a hollow fiber membrane bundle. ASAIO J 55:569-74
Svitek, R G; Federspiel, W J (2008) A mathematical model to predict CO2 removal in hollow fiber membrane oxygenators. Ann Biomed Eng 36:992-1003

Showing the most recent 10 out of 21 publications