The objective of the proposed project is to develop a real time high frequency ultrasound imaging system capable of pulsed Doppler with a frame rate higher than 150 Hz for cardiac applications in small animals. Ultrasound imaging is a well established technology for cardiac imaging on humans. For cardiac imaging in small animals whose hearts beat at a rate higher than 200 beats/minute, the spatial and temporal resolutions of current clinical ultrasonic scanners are far from ideal and simply inadequate for such applications. Furthermore current commercial high frequency ultrasonic scanners developed for small animal imaging and eye imaging in humans are incapable of producing images at a frame rate higher than 30 Hz. The device to be designed and fabricated will be a mechanical sector scanner with a single element transducer capable of imaging the heart of small animals at a frequency from 30 to 50 MHz at a frame rate of at least 150 Hz. The proposed scanner will consist of a probe and an imaging unit that will be based on existing technology and commercial components. The design and fabrication of the probe will be the heart of the project. It will be developed in collaboration with Capistrano Lab by integrating a single element high frequency transducer with an f-number of 2 to 4 with a servo motor system. The USC group has expertise in transducer engineering and imaging system development whereas Capistrano labs Inc. has produced a similar probe which is commercially available but at a lower frame rate. The probe will be designed and built at Capistrano. The imaging unit, the Pulsed Doppler unit, and transducers will be designed and built at USC. System integration of the probe and the imaging console will also be carried out at USC. Upon the completion of this research it is expected that a prototype system will be designed and tested on wire and flow phantoms, excised mouse hearts in vitro and live animals in vivo.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL079976-01
Application #
6901645
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Pandit, Sunil
Project Start
2005-03-01
Project End
2008-02-29
Budget Start
2005-03-01
Budget End
2006-02-28
Support Year
1
Fiscal Year
2005
Total Cost
$293,750
Indirect Cost
Name
University of Southern California
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Kang, Bong Jin; Park, Jinhyoung; Kim, Jieun et al. (2015) High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts. J R Soc Interface 12:
Park, Jinhyoung; Li, Xiang; Zhou, Qifa et al. (2013) Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20-60 MHz phantom and ex vivo results. Ultrasonics 53:369-76
Park, Jinhyoung; Cummins, Thomas M; Harrison, Michael et al. (2013) High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart. Opt Express 21:14636-42
Qiu, Weibao; Yu, Yanyan; Chabok, Hamid Reza et al. (2013) A flexible annular-array imaging platform for micro-ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 60:178-86
Park, Jinhyoung; Huang, Ying; Chen, Ruimin et al. (2013) Pulse inversion chirp coded tissue harmonic imaging (PI-CTHI) of Zebrafish heart using high frame rate ultrasound biomicroscopy. Ann Biomed Eng 41:41-52
Zhou, Xiaowei; Sun, Lei; Yu, Yanyan et al. (2013) Ultrasound bio-microscopic image segmentation for evaluation of zebrafish cardiac function. IEEE Trans Ultrason Ferroelectr Freq Control 60:718-26
Liu, Changgeng; Djuth, Frank; Li, Xiang et al. (2012) Micromachined high frequency PMN-PT/epoxy 1-3 composite ultrasonic annular array. Ultrasonics 52:497-502
Hwang, Jae Youn; Park, Jinhyoung; Kang, Bong Jin et al. (2012) Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. PLoS One 7:e34463
Park, Jinhyoung; Hu, Changhong; Li, Xiang et al. (2012) Wideband linear power amplifier for high-frequency ultrasonic coded excitation imaging. IEEE Trans Ultrason Ferroelectr Freq Control 59:825-32
Park, Jinhyoung; Lee, Jungwoo; Lau, Sien Ting et al. (2012) Acoustic radiation force impulse (ARFI) imaging of zebrafish embryo by high-frequency coded excitation sequence. Ann Biomed Eng 40:907-15

Showing the most recent 10 out of 20 publications