The purpose of this four year project is to determine how much, how vigorous and what patterns of physical activity are necessary to maintain cardiovascular health among older women. Accelerometers will be used to characterize the amounts and patterns of physical activity. In a cohort of 8000 WHI participants aged 80 and older we will: 1) Determine the association of total volume of physical activity (light, moderate and vigorous) as measured by accelerometry with rates of incident CVD and total mortality;2) Determine the associations of moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with rates of incident CVD and total mortality;2.1) Conduct a calibration study designed to determine accelerometry thresholds for women aged 80 and older that distinguish sedentary from light activity and light activity from moderate to vigorous activity in order to make Aim 2 directly relevant to older women;3) Compare the magnitude and independence of associations between accelerometer measures of physical activity and sedentary time, and self-reported measures of MVPA and sedentary time, with rates of incident CVD and total mortality;and 4) Determine associations of total volume of physical activity, MVPA and sedentary time with rates of fall-related injuries and overall risk for any injury. To accomplish these aims, 8,000 face-to-face visits will be conducted nationwide among women aged 80 and older from the Women's Health Initiative (WHI) who were originally enrolled between 1993-1997. Participants will wear an accelerometer for 7 days, complete a questionnaire containing the CHAMPS and WHI physical activity scales, and the Falls Efficacy Scale, and be followed through at least 2015 (3-4 years) to ascertain study outcomes. For the calibration study, two WHI clinics will recruit 200 women for participation in a clinic visit to measure energy expenditure during various activities using indirect calorimetry. This evidence is crucial for formulating evidence-based physical activity guidelines that pertain to the growing population of older women in the US and worldwide.
This study is aimed at determining how much total physical activity, including light and moderate or vigorous activity, is needed to reduce risk of cardiovascular events and total mortality among older women aged 80 and older. The study will also determine whether sedentary time is related to risk of cardiovascular events. Information on physical activity will be collected by asking women to wear a small device, called an accelerometer, for 7 days, as well as filling out a questionnaire about their physical activities.
|LaMonte, Michael J; Buchner, David M; Rillamas-Sun, Eileen et al. (2018) Accelerometer-Measured Physical Activity and Mortality in Women Aged 63 to 99. J Am Geriatr Soc 66:886-894|
|Shadyab, Aladdin H; LaMonte, Michael J; Kooperberg, Charles et al. (2017) Leisure-time physical activity and leukocyte telomere length among older women. Exp Gerontol 95:141-147|
|LaCroix, Andrea Z; Rillamas-Sun, Eileen; Buchner, David et al. (2017) The Objective Physical Activity and Cardiovascular Disease Health in Older Women (OPACH) Study. BMC Public Health 17:192|
|Buchner, David M; Rillamas-Sun, Eileen; Di, Chongzhi et al. (2017) Accelerometer-Measured Moderate to Vigorous Physical Activity and Incidence Rates of Falls in Older Women. J Am Geriatr Soc 65:2480-2487|
|Shadyab, Aladdin H; LaMonte, Michael J; Kooperberg, Charles et al. (2017) Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women. J Gerontol A Biol Sci Med Sci 72:1532-1537|
|Shadyab, Aladdin H; Macera, Caroline A; Shaffer, Richard A et al. (2017) Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women. Am J Epidemiol 185:172-184|
|Bai, Jiawei; Di, Chongzhi; Xiao, Luo et al. (2016) An Activity Index for Raw Accelerometry Data and Its Comparison with Other Activity Metrics. PLoS One 11:e0160644|
|Evenson, Kelly R; Wen, Fang; Herring, Amy H et al. (2015) Calibrating physical activity intensity for hip-worn accelerometry in women age 60 to 91 years: The Women's Health Initiative OPACH Calibration Study. Prev Med Rep 2:750-756|
|Rosenberg, Dori E; Lee, I-Min; Young, Deborah Rohm et al. (2015) Novel strategies for sedentary behavior research. Med Sci Sports Exerc 47:1311-5|
|Rillamas-Sun, Eileen; Buchner, David M; Di, Chongzhi et al. (2015) Development and application of an automated algorithm to identify a window of consecutive days of accelerometer wear for large-scale studies. BMC Res Notes 8:270|