The long term goal of this research proposal is to develop comprehensive accurate quantitative methods for quantitative dynamic cardiac PET that can be used in the clinical setting. Dynamic PET has long been a mainstay for research applications. However, several new PET radiopharmaceuticals require quantitative dynamic imaging with kinetic analysis to reach their clinical potential. Our work is motivated by the need to maximize the useful physiological information that can be obtained with PET while improving image quality and reducing imaging time. We envision the development of automated processing that will be transparent, transforming dynamic data to quantitative parametric maps with little operator intervention. We choose to validate our methods in cardiac imaging, given the health burden of coronary artery disease (CAD), the medical significance of quantitative cardiac PET (absolute myocardial blood flow (MBF) and coronary flow reserve (CFR)) in identifying balanced ischemia and quantifying response to treatment (e.g., CABG, PTCA), and the potential impact on CAD management of novel 18F-based flow agents. Furthermore, simultaneous dynamic rest-stress PET can reduce imaging duration while minimizing clinical artifacts associated differences between rest and stress studies in terms of patient motion, positioning, and attenuation paths. The impact of our research is not limited, however, to the heart, it extends to other applications in the brain (e.g., neuroreceptor density), cancer (e.g., tumor blood flow), etc. Many approaches to improving quantitation for dynamic PET have been proposed, but have not made it to the clinic due to the challenging noise conditions in short dynamic frames and lack of comprehensive quantitative strategies and automated software. In this proposal, we propose two approaches for absolute quantitation of MBF that operate on reconstructed frames or directly on listmode data. Next, we extend our methods to the more challenging case of simultaneous dynamic rest-stress cardiac PET to achieve joint estimation of rest and peak stress kinetic parameters and validate our methods in an acute ischemic porcine model.

Public Health Relevance

Many approaches to improving quantitation for dynamic PET have been proposed, but have not made it to the clinic due to the challenging noise conditions in short dynamic frames and lack of comprehensive quantitative strategies and automated software. In this proposal, we propose two approaches for absolute quantitation of MBF that operate on reconstructed frames or directly on listmode data. Next, we extend our methods to the more challenging case of simultaneous dynamic rest-stress cardiac PET to achieve joint estimation of rest and peak stress kinetic parameters. Finally, we validate our methods in an acute porcine ischemic animal model.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL110241-04
Application #
8708947
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Danthi, Narasimhan
Project Start
2011-09-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Zhu, W; Ouyang, J; Rakvongthai, Y et al. (2016) A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography. Med Phys 43:1222-34
Zhang, Xiaomeng; Chen, Yen-Lin E; Lim, Ruth et al. (2016) Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging. Magn Reson Imaging 34:276-9
Huang, C; Ouyang, J; Reese, T G et al. (2015) Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR. Phys Med Biol 60:N369-81
Herraiz, J L; Sitek, A (2015) Sensitivity estimation in time-of-flight list-mode positron emission tomography. Med Phys 42:6690-702
Grogg, Kira; Alpert, Nathaniel M; Zhu, Xuping et al. (2015) Mapping (15)O production rate for proton therapy verification. Int J Radiat Oncol Biol Phys 92:453-9
Dutta, Joyita; Huang, Chuan; Li, Quanzheng et al. (2015) Pulmonary imaging using respiratory motion compensated simultaneous PET/MR. Med Phys 42:4227-40
Normandin, Marc D; Yuan, Hushan; Wilks, Moses Q et al. (2015) Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl 54:13002-6
Huang, Chuan; Petibon, Yoann; Ouyang, Jinsong et al. (2015) Accelerated acquisition of tagged MRI for cardiac motion correction in simultaneous PET-MR: phantom and patient studies. Med Phys 42:1087-97
Ouyang, Jinsong; Petibon, Yoann; Huang, Chuan et al. (2014) Quantitative Simultaneous PET-MR Imaging. J Med Imaging (Bellingham) 9083:908325
Schaefferkoetter, Joshua; Ouyang, Jinsong; Rakvongthai, Yothin et al. (2014) Effect of time-of-flight and point spread function modeling on detectability of myocardial defects in PET. Med Phys 41:062502

Showing the most recent 10 out of 33 publications