This is a competing renewal application for grant support of research whose general goal is to understand the biological bases of motivated behavior, especially thirst, salt appetite, hunger and satiety. Three series of experiments are proposed. Experiment 1 seeks to determine the early postingestive signals that influence thirst and the secretion of vasopressin (VP) and oxytocin (OT) in rats. In pursuit of this aim, we will determine (a) whether water drinking reduces secretion of VP and OT in response to excitatory stimuli other than that provided by an intravenous NaCl load; (b) whether lesions of area postrema and nucleus tractus solitarius (NTS) blunt the rapid effect of water drinking, or of an intragastric NaCl load, on secretion of VP and OT; and (c) whether maintenance of rats on high-salt diet blunts the rapid inhibitory effect of water drinking on VP and OT secretion. Experiment 2 seeks to determine the excitatory stimuli for thirst during arterial hypotension or hypovolemia, and the inhibitory stimulus for thirst during arterial hypertension. In pursuit of this aim, we will determine (a) whether angiotensin II and neural signals from arterial baroreceptors contribute significantly to thirst during hypotension; (b) whether renal afferent nerves contribute significantly to thirst during hypovolemia in rats with NTS lesions; and (c) whether sinoaortic baroreceptors contribute significantly to the inhibitory effect of arterial hypertension on thirst. Experiment 3 seeks to determine the physiological functions of neurohypophyseal OT secretion in rats given NaCl loads or during arterial hypotension. In pursuit of this aim, we will determine (a) whether OT contributes significantly as a natriuretic hormone when rats are maintained on high-salt diet; and (b) whether OT contributes significantly to secretion of renin during arterial hypotension, and thus to mediation of the induced thirst.
| Stricker, Edward M (2016) 2015 Distinguished career award: Reflections on a career in science. Physiol Behav 162:196-200 |
| Bykowski, Michael R; Smith, James C; Stricker, Edward M (2007) Regulation of NaCl solution intake and gastric emptying in adrenalectomized rats. Physiol Behav 92:781-9 |
| Smith, Carrie A; Curtis, Kathleen S; Smith, James C et al. (2007) Presystemic influences on thirst, salt appetite, and vasopressin secretion in the hypovolemic rat. Am J Physiol Regul Integr Comp Physiol 292:R2089-99 |
| Stricker, Edward M; Hoffmann, Myriam L (2007) Presystemic signals in the control of thirst, salt appetite, and vasopressin secretion. Physiol Behav 91:404-12 |
| Stricker, Edward M; Bushey, Michael A; Hoffmann, Myriam L et al. (2007) Inhibition of NaCl appetite when DOCA-treated rats drink saline. Am J Physiol Regul Integr Comp Physiol 292:R652-62 |
| Hoffmann, Myriam L; DenBleyker, Megan; Smith, James C et al. (2006) Inhibition of thirst when dehydrated rats drink water or saline. Am J Physiol Regul Integr Comp Physiol 290:R1199-207 |
| Manesh, Reza; Hoffmann, Myriam L; Stricker, Edward M (2006) Water ingestion by rats fed a high-salt diet may be mediated, in part, by visceral osmoreceptors. Am J Physiol Regul Integr Comp Physiol 290:R1742-9 |
| Stricker, Edward M; Hoffmann, Myriam L; Riccardi, Christiana J et al. (2003) Increased water intake by rats maintained on high NaCl diet: analysis of ingestive behavior. Physiol Behav 79:621-31 |
| Stocker, Sean D; Smith, Carrie A; Kimbrough, Celeste M et al. (2003) Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats. Am J Physiol Regul Integr Comp Physiol 284:R1521-8 |
| Stricker, Edward M; Sved, Alan F (2002) Controls of vasopressin secretion and thirst: similarities and dissimilarities in signals. Physiol Behav 77:731-6 |
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