Depression which interferes with maternal role functioning occurs in 10 to 15 percent of postpartum women. This disorder causes personal and family suffering at a time when adaptation to the tasks of parenthood is critical. Rapid provision of effective treatment is imperative to prevent the consequences of maternal illness. However, there are no controlled pharmacologic treatment studies of women with postpartum major depression (PPMD). The purpose of this study is to conduct a double-blind, randomized clinical trial of sertraline (SERT) compared to nortripytyline (NTP) for the treatment for PPMD. The proposed study is a fixed-dose, 8 week clinical trail. The hypothesis is that a SERT tnan to NPT as defined by measures of symptom reduction and psychosocial function. Secondary hypotheses are: 1) the side effect burden of women treated with SERT will be less than with NTP; 2) depressed women with aggressive obsessional thoughts will respond more favorably to SERT; and 3) specific clinical variables will be associated with drug response (depression severity, personality disorder, marital disaffection, and psychosocial problems).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
7R01MH057102-06
Application #
6709758
Study Section
Special Emphasis Panel (ZMH1-CRB-J (O1))
Project Start
1997-04-01
Project End
2004-03-31
Budget Start
2002-09-01
Budget End
2004-03-31
Support Year
6
Fiscal Year
2001
Total Cost
$80,783
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Moses-Kolko, Eydie L; Price, Julie C; Wisner, Katherine L et al. (2012) Postpartum and depression status are associated with lower [[¹¹C]raclopride BP(ND) in reproductive-age women. Neuropsychopharmacology 37:1422-32
Sit, Dorothy; Perel, James M; Wisniewski, Stephen R et al. (2011) Mother-infant antidepressant concentrations, maternal depression, and perinatal events. J Clin Psychiatry 72:994-1001

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