Abstract

Biophysical measurements will be made of the heat production of non-myelinated nerve fibers during and soon after the impulse, together with electrical measurements of the post-tetanic hyperpolarization (which reflects the activity of the sodium pump, and pharmacological measurements of the interaction of drugs with the nerve membrane (tetrodotoxin, saxitoxin, local anesthetics). The turnover of intracellular phosphate, particularly nucleotide phosphate, and the oxygen consumption will be measured. These measurements will all be used in an integrated approach to the molecular basis of conduction and of the subsequent recovery processes in mammalian non-myelinated nerve fibers. These fibers, because of their small size, have a large surface/volume ratio and hence are extremely suitable for such a study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS008304-18
Application #
3393737
Study Section
Physiology Study Section (PHY)
Project Start
1979-01-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
18
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code

  Publications

Baker, M D; Ritchie, J M (1994) The action of capsaicin on type I delayed rectifier K+ currents in rabbit Schwann cells. Proc Biol Sci 255:259-65
Utzschneider, D A; Thio, C; Sontheimer, H et al. (1993) Action potential conduction and sodium channel content in the optic nerve of the myelin-deficient rat. Proc Biol Sci 254:245-50
Watson, J T; Robertson, J; Sachdev, U et al. (1993) Laryngeal muscle and motor neuron plasticity in Xenopus laevis: testicular masculinization of a developing neuromuscular system. J Neurobiol 24:1615-25
Baker, M; Howe, J R; Ritchie, J M (1993) Two types of 4-aminopyridine-sensitive potassium current in rabbit Schwann cells. J Physiol 464:321-42
Watson, J T; Kelley, D B (1992) Testicular masculinization of vocal behavior in juvenile female Xenopus laevis reveals sensitive periods for song duration, rate, and frequency spectra. J Comp Physiol A 171:343-50
Howe, J R; Baker, M; Ritchie, J M (1992) On the block of outward potassium current in rabbit Schwann cells by internal sodium ions. Proc Biol Sci 249:309-16
Howe, J R; Ritchie, J M (1992) Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells. J Physiol 455:529-66
Ritchie, J M (1991) Current perspectives in glial electrophysiology. Ann N Y Acad Sci 633:331-42
Howe, J R; Ritchie, J M (1991) On the active form of 4-aminopyridine: block of K+ currents in rabbit Schwann cells. J Physiol 433:183-205
Howe, J R; Ritchie, J M (1990) Sodium currents in Schwann cells from myelinated and non-myelinated nerves of neonatal and adult rabbits. J Physiol 425:169-210

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