Songbirds are one of the few animal models for human speech in which it is possible to experimentally investigate basic physiological and acoustic challenges associated with producing complex, learned vocalizations. Parallels between the production of speech and birdsong have recently been strengthened by the discovery in birds of new song-related motor programs that modulate the dimensions of the supra glottal vocal tract, causing it to act as a variable resonance filter that tracks the fundamental frequency of sound generated in the vocal organ. The following research focuses on sensorimotor control of the oropharyngeal-esophageal cavity (OEC), which dominates the vocal tract filter. A long-term goal is to increase our understanding of how the nervous system controls complex behaviors. The first specific aim is to perform a detailed functional morphological analysis of the songbird head and neck, using micro dissection, MRI and CT scan. The data obtained will be combined with that from cineradiography of vocal tract movements during song. The resulting kinematic model will be elaborated by the addition of in vivo and in vitro measures of biophysical, physiological and biochemical factors determining the contractile performance of the relevant vocal tract muscles. The inclusion of these data in the model will make it possible to convert the kinematic model into a dynamic 3D biomechanical model of song-related vocal tract movements. The second specific aim investigates the role of sensory feedback in the OEC's ability to keep its resonance frequency tuned to the song's fundamental frequency, which is controlled by the syrinx. Cineradiography will be combined with manipulation of sensory feedback by deafening, pitch shifting vocal output or altering the fundamental frequency to determine the role of sensory feedback in controlling vocal tract filters so their resonance matches the fundamental frequency. The possible role of somatosensory feedback in tuning the vocal tract filter will also be investigated. The third specific aim will use neuroanatomical and neurophysiological techniques to map the premotor pathways of the cranial nerves in order to identify the neural pathways by which auditory information accesses the motoneurons to muscles of the upper vocal tract and to look for possible neural connections to the brain's song control nuclei, which controls the vocal organ. Songbirds provide a valuable model system in which to investigate some of the control mechanisms relevant to various speech pathologies that are important to public health.

Public Health Relevance

Disorders of speech are of substantial significance, yet animal models in which to study the physiological basis of learned vocal communication are surprisingly rare. The role of sensory feedback in motor coordination during speech production is poorly understood. The knowledge gained from this research will improve our understanding of the integration between the vocal organ and articulatory movements of the upper vocal tract and have implications for speech fluency disorders, including stuttering.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029467-18
Application #
8402399
Study Section
Special Emphasis Panel (ZRG1-IFCN-B (03))
Program Officer
Chen, Daofen
Project Start
1991-05-01
Project End
2014-12-31
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
18
Fiscal Year
2013
Total Cost
$310,220
Indirect Cost
$99,126
Name
Indiana University-Purdue University at Indianapolis
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Schmidt, Marc F; Martin Wild, J (2014) The respiratory-vocal system of songbirds: anatomy, physiology, and neural control. Prog Brain Res 212:297-335
Medina, Felipe S; Hunt, Gavin R; Gray, Russell D et al. (2013) Perineuronal satellite neuroglia in the telencephalon of New Caledonian crows and other Passeriformes: evidence of satellite glial cells in the central nervous system of healthy birds? PeerJ 1:e110
Wild, J M; Krutzfeldt, N E O (2012) Trigeminal and telencephalic projections to jaw and other upper vocal tract premotor neurons in songbirds: Sensorimotor circuitry for beak movements during singing. J Comp Neurol 520:590-605
Ohms, Verena R; Beckers, Gabriel J L; ten Cate, Carel et al. (2012) Vocal tract articulation revisited: the case of the monk parakeet. J Exp Biol 215:85-92
Suthers, Roderick A; Wild, J Martin; Kaplan, Gisela (2011) Mechanisms of song production in the Australian magpie. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 197:45-59
Krutzfeldt, Nils O E; Logerot, Priscilla; Kubke, M Fabiana et al. (2010) Connections of the auditory brainstem in a songbird, Taeniopygia guttata. I. Projections of nucleus angularis and nucleus laminaris to the auditory torus. J Comp Neurol 518:2109-34
Wild, J Martin; Krutzfeldt, Nils O E; Kubke, M Fabiana (2010) Connections of the auditory brainstem in a songbird, Taeniopygia guttata. III. Projections of the superior olive and lateral lemniscal nuclei. J Comp Neurol 518:2149-67
Krutzfeldt, Nils O E; Logerot, Priscilla; Kubke, M Fabiana et al. (2010) Connections of the auditory brainstem in a songbird, Taeniopygia guttata. II. Projections of nucleus angularis and nucleus laminaris to the superior olive and lateral lemniscal nuclei. J Comp Neurol 518:2135-48
Riede, Tobias; Suthers, Roderick A (2009) Vocal tract motor patterns and resonance during constant frequency song: the white-throated sparrow. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:183-92
Wild, J M; Kubke, M F; Mooney, R (2009) Avian nucleus retroambigualis: cell types and projections to other respiratory-vocal nuclei in the brain of the zebra finch (Taeniopygia guttata). J Comp Neurol 512:768-83

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