Public Health Relevance

Epilepsy is the third most common major neurologic disease, and infancy and childhood are windows of higher incidence. Almost half of all epilepsy patients suffer some sort of cognitive and psychiatric disorders, and the incidence of cognitive problems including autism is high in children with epilepsy. Likewise, there is a higher incidence of epilepsy in autism and other intellectual developmental disorders. Here we evaluate whether epilepsy can affect the normal processes of early brain development, and whether there are molecular targets for intervention and treatment to reverse these changes. This grant application addresses several components of the Epilepsy Research Benchmarks (http://www.ninds.nih.gov/research/epilepsyweb/2007_benchmarks.htm ) Benchmarks Area III: Prevent, limit, and reverse the co-morbidities associated with epilepsy and its treatment. B. Identify predictors and underlying mechanisms that contribute to co-morbidities. C. Determine the optimal treatments for the neuropsychiatric and cognitive comorbidities in people with epilepsy. D. Prevent or limit other adverse consequences occurring in people with epilepsy . Public Health

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS080565-01A1S1
Application #
8811309
Study Section
Clinical Neuroplasticity and Neurotransmitters Study Section (CNNT)
Program Officer
Whittemore, Vicky R
Project Start
2013-08-01
Project End
2017-05-31
Budget Start
2013-08-01
Budget End
2014-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$2,237
Indirect Cost
$839
Name
University of Pennsylvania
Department
Neurology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104