The proposed study will examine the extent to which extant behavioral drug abuse treatments are effective as an HIV prevention strategy using an integrative data analysis (IDA) approach. IDA allows for analysis of multiple original data sets that have been pooled into one using harmonized variables. This research will pool data from behavioral drug abuse treatments conducted through the National Institute on Drug Abuse's (NIDA) Clinical Trials Network (CTN). Specifically, this research will: (1) create a pooled data se with harmonized variables and corresponding harmonized data codebook combining data from 15 individual NIDA CTN behavioral drug abuse treatment trials (N=6,896 unique participants);(2) evaluate the extent to which NIDA CTN behavioral drug abuse treatments reduce HIV transmission risk behaviors defined as injection drug use, needle sharing, and sexual risk behaviors (e.g., unprotected sexual intercourse, trading sex for drugs) using the pooled data set with harmonized variables;and (3) examine potential moderators of the effectiveness of NIDA CTN behavioral drug abuse treatments to reduce HIV transmission risk behaviors. Core moderating factors that will be examined are sampling characteristics (e.g., age, gender, race/ethnicity, baseline drug use behavior engagement) and study design features (e.g., inclusion of HIV risk reduction intervention content, intervention modality, intervention length). Results from the proposed research will provide requisite information to guide the development, adaptation, and dissemination of future interventions to reduce and prevent both drug abuse and HIV.

Public Health Relevance

This study will examine the effectiveness of behavioral drug abuse treatments to reduce HIV transmission risk behaviors and explore factors that moderate intervention effectiveness. This research will utilize data pooled from completed behavioral drug abuse treatment trials within the National Institute on Drug Abuse's Clinical Trials Network. Results from this research will inform the development, adaptation, and dissemination of future treatments to reduce and prevent both drug abuse and HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Small Research Grants (R03)
Project #
1R03DA037786-01
Application #
8731380
Study Section
Special Emphasis Panel (ZRG1-AARR-C (82))
Program Officer
Aklin, Will
Project Start
2014-05-01
Project End
2016-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$158,282
Indirect Cost
$39,401
Name
Texas Tech University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041367053
City
Lubbock
State
TX
Country
United States
Zip Code
79409
Littlefield, Andrew K; Brown, Jennifer L; DiClemente, Ralph J et al. (2017) Phosphatidylethanol (PEth) as a Biomarker of Alcohol Consumption in HIV-Infected Young Russian Women: Comparison to Self-Report Assessments of Alcohol Use. AIDS Behav 21:1938-1949
Brown, Jennifer L; Gause, Nicole K; Northern, Nathan (2016) The Association between Alcohol and Sexual Risk Behaviors among College Students: A Review. Curr Addict Rep 3:349-355
Brown, Jennifer L; Talley, Amelia E; Littlefield, Andrew K et al. (2016) Young women's alcohol expectancies for sexual risk-taking mediate the link between sexual enhancement motives and condomless sex when drinking. J Behav Med 39:925-30
Swartzendruber, Andrea; Sales, Jessica M; Brown, Jennifer L et al. (2016) Comparison of Substance Use Typologies as Predictors of Sexual Risk Outcomes in African American Adolescent Females. Arch Sex Behav 45:63-72
Brown, Jennifer L; DiClemente, Ralph J; Sales, Jessica M et al. (2016) Substance Use Patterns of HIV-Infected Russian Women with and Without Hepatitis C Virus Co-infection. AIDS Behav 20:2398-2407
Brown, Jennifer L; DiClemente, Ralph J; Sales, Jessica M et al. (2016) Alcohol Use, Partner Characteristics, and Condom Use Among HIV-Infected Russian Women: An Event-Level Study. J Stud Alcohol Drugs 77:968-973
Stevens, Angela K; Littlefield, Andrew K; Blanchard, Brittany E et al. (2016) Does drinking refusal self-efficacy mediate the impulsivity-problematic alcohol use relation? Addict Behav 53:181-6
Brown, Jennifer L; DiClemente, Ralph J (2015) The Need for Biological Outcomes to Complement Self-Report in Adolescent Research. Pediatrics 136:e551-3
Hulland, Erin N; Brown, Jennifer L; Swartzendruber, Andrea L et al. (2015) The association between stress, coping, and sexual risk behaviors over 24 months among African-American female adolescents. Psychol Health Med 20:443-56
Brown, Jennifer L; Sales, Jessica M; DiClemente, Ralph J (2014) Combination HIV prevention interventions: the potential of integrated behavioral and biomedical approaches. Curr HIV/AIDS Rep 11:363-75

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