The proposed study will examine the extent to which extant behavioral drug abuse treatments are effective as an HIV prevention strategy using an integrative data analysis (IDA) approach. IDA allows for analysis of multiple original data sets that have been pooled into one using harmonized variables. This research will pool data from behavioral drug abuse treatments conducted through the National Institute on Drug Abuse's (NIDA) Clinical Trials Network (CTN). Specifically, this research will: (1) create a pooled data se with harmonized variables and corresponding harmonized data codebook combining data from 15 individual NIDA CTN behavioral drug abuse treatment trials (N=6,896 unique participants);(2) evaluate the extent to which NIDA CTN behavioral drug abuse treatments reduce HIV transmission risk behaviors defined as injection drug use, needle sharing, and sexual risk behaviors (e.g., unprotected sexual intercourse, trading sex for drugs) using the pooled data set with harmonized variables;and (3) examine potential moderators of the effectiveness of NIDA CTN behavioral drug abuse treatments to reduce HIV transmission risk behaviors. Core moderating factors that will be examined are sampling characteristics (e.g., age, gender, race/ethnicity, baseline drug use behavior engagement) and study design features (e.g., inclusion of HIV risk reduction intervention content, intervention modality, intervention length). Results from the proposed research will provide requisite information to guide the development, adaptation, and dissemination of future interventions to reduce and prevent both drug abuse and HIV.
This study will examine the effectiveness of behavioral drug abuse treatments to reduce HIV transmission risk behaviors and explore factors that moderate intervention effectiveness. This research will utilize data pooled from completed behavioral drug abuse treatment trials within the National Institute on Drug Abuse's Clinical Trials Network. Results from this research will inform the development, adaptation, and dissemination of future treatments to reduce and prevent both drug abuse and HIV.
|Brown, Jennifer L; Eriksen, Michael D; Gause, Nicole K et al. (2018) Impact of Behavioral Drug Abuse Treatment on Sexual Risk Behaviors: An Integrative Data Analysis of Eight Trials Conducted Within the National Drug Abuse Treatment Clinical Trials Network. Prev Sci 19:761-771|
|Brown, Jennifer L; Winhusen, Theresa; DiClemente, Ralph J et al. (2017) The association between cigarette smoking, virologic suppression, and CD4+ lymphocyte count in HIV-Infected Russian women. AIDS Care 29:1102-1106|
|Littlefield, Andrew K; Brown, Jennifer L; DiClemente, Ralph J et al. (2017) Phosphatidylethanol (PEth) as a Biomarker of Alcohol Consumption in HIV-Infected Young Russian Women: Comparison to Self-Report Assessments of Alcohol Use. AIDS Behav 21:1938-1949|
|Brown, Jennifer L; Gause, Nicole K; Northern, Nathan (2016) The Association between Alcohol and Sexual Risk Behaviors among College Students: A Review. Curr Addict Rep 3:349-355|
|Brown, Jennifer L; DiClemente, Ralph J; Sales, Jessica M et al. (2016) Substance Use Patterns of HIV-Infected Russian Women with and Without Hepatitis C Virus Co-infection. AIDS Behav 20:2398-2407|
|Swartzendruber, Andrea; Sales, Jessica M; Brown, Jennifer L et al. (2016) Comparison of Substance Use Typologies as Predictors of Sexual Risk Outcomes in African American Adolescent Females. Arch Sex Behav 45:63-72|
|Brown, Jennifer L; DiClemente, Ralph J; Sales, Jessica M et al. (2016) Alcohol Use, Partner Characteristics, and Condom Use Among HIV-Infected Russian Women: An Event-Level Study. J Stud Alcohol Drugs 77:968-973|
|Brown, Jennifer L; Talley, Amelia E; Littlefield, Andrew K et al. (2016) Young women's alcohol expectancies for sexual risk-taking mediate the link between sexual enhancement motives and condomless sex when drinking. J Behav Med 39:925-30|
|Stevens, Angela K; Littlefield, Andrew K; Blanchard, Brittany E et al. (2016) Does drinking refusal self-efficacy mediate the impulsivity-problematic alcohol use relation? Addict Behav 53:181-6|
|Brown, Jennifer L; DiClemente, Ralph J (2015) The Need for Biological Outcomes to Complement Self-Report in Adolescent Research. Pediatrics 136:e551-3|
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