The advent of implantable blood recirculating devices has provided life saving solutions to patients with severe cardiovascular diseases. Ventricular assist devices (VAD), blood pumps, and prosthetic heart valves (PHV) provide short to long term solutions for such patients. However, blood clots formation and the attendant risk for stroke remains an impediment to these devices. The complex life-long anticoagulant drug regimen they require, which induces vulnerability to hemorrhage and is not a viable therapy for some patients, does not eliminate this risk. Clot formation is potentiated by contact with foreign surfaces and the non-physiologic flow patterns that enhance the hemostatic response by chronically activating platelets. It is now recognized as the salient aspect of blood trauma in devices. We offer to develop state of the art multiscale numerical simulation methodology that will be able to predict and depict flow induced thrombogenicity in devices. Stresses induced by blood flow on platelets can be represented by a continuum mechanics models down to the order of the

Public Health Relevance

Better understanding of the complex interactions between living tissues and mechanical stimuli, as represented by the vexing problem of flow-induced cardiovascular devices thrombogenicity, calls for innovative multidisciplinary approaches that couple biophysical and biochemical transport phenomena spanning the spatial and temporal scales. In this proposal a multi-scale modeling approach will be developed that will efficiently utilize high performance computing (HPC) resources. The knowledge that will be gained by the proposed research is essential for developing the next generation of devices that will reduce mortality rates, improve patients'quality of life, and reduce the ensuing healthcare costs. The innovative methodology that will be developed may stimulate the burgeoning field of multiscale simulations and its application to solving complex clinical problems at the interface of engineering and biology. It has the potential to advance our understanding of biotransport processes to a new level that will have a major impact on important problems in biology and medicine.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Exploratory/Developmental Grants (R21)
Project #
Application #
Study Section
Bioengineering, Technology and Surgical Sciences Study Section (BTSS)
Program Officer
Baldwin, Tim
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
State University New York Stony Brook
Biomedical Engineering
Schools of Engineering
Stony Brook
United States
Zip Code
Zhang, Peng; Zhang, Li; Slepian, Marvin J et al. (2017) A multiscale biomechanical model of platelets: Correlating with in-vitro results. J Biomech 50:26-33
Slepian, Marvin J; Sheriff, Jawaad; Hutchinson, Marcus et al. (2017) Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis. J Biomech 50:20-25
Zhang, Peng; Zhang, Na; Gao, Chao et al. (2016) Scalability Test of Multiscale Fluid-Platelet Model for Three Top Supercomputers. Comput Phys Commun 204:132-140
Pothapragada, Seetha; Zhang, Peng; Sheriff, Jawaad et al. (2015) A phenomenological particle-based platelet model for simulating filopodia formation during early activation. Int J Numer Method Biomed Eng 31:e02702
Zhang, Peng; Zhang, Na; Deng, Yuefan et al. (2015) A Multiple Time Stepping Algorithm for Efficient Multiscale Modeling of Platelets Flowing in Blood Plasma. J Comput Phys 284:668-686
Bluestein, Danny; Soares, João S; Zhang, Peng et al. (2014) Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics and Molecular Dynamics. J Med Device 8:0209541-209542
Zhang, Na; Zhang, Peng; Kang, Wei et al. (2014) Parameterizing the Morse Potential for Coarse-Grained Modeling of Blood Plasma. J Comput Phys 257:726-736
Zhang, Peng; Gao, Chao; Zhang, Na et al. (2014) Multiscale Particle-Based Modeling of Flowing Platelets in Blood Plasma Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics. Cell Mol Bioeng 7:552-574
Soares, Joao S; Gao, Chao; Alemu, Yared et al. (2013) Simulation of platelets suspension flowing through a stenosis model using a dissipative particle dynamics approach. Ann Biomed Eng 41:2318-33