Nonhuman primates serve as crucial animal models for exploring the pathogenesis of infectious and noninfectious diseases, and for testing of new therapies and vaccines that cannot be evaluated in small animal models. This grant established the Nonhuman Primate Reagent Resource, a program for developing, manufacturing and distributing antibody-based reagents that deplete specific lymphocyte subpopulations or target specific immune functions in vivo. These novel reagents serve to optimize the use of nonhuman primates across multiple scientific disciplines. We will continue to serve as a resource laboratory, and take advantage of scientific advances and technological improvements by expanding the number and type of reagents we make available to biomedical investigators.

Public Health Relevance

The Nonhuman Primate Reagent Resource develops, manufactures and distributes antibody research reagents for use as tools in nonhuman primate models of disease. These antibody tools help investigators to develop treatments and vaccines for many different infectious diseases. Some antibodies are also being evaluated as therapeutics for autoimmune diseases and in organ transplantation.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Resource-Related Research Projects (R24)
Project #
5R24OD010976-17
Application #
9199109
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Watson, Harold L
Project Start
2000-09-01
Project End
2019-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
17
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Miscellaneous
Type
Overall Medical
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Srinivasula, Sharat; Gabriel, Erin; Kim, Insook et al. (2017) CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies. PLoS One 12:e0187912
Nishimura, Yoshiaki; Gautam, Rajeev; Chun, Tae-Wook et al. (2017) Early antibody therapy can induce long-lasting immunity to SHIV. Nature 543:559-563
Shin, Jun-Seop; Kim, Jong-Min; Min, Byoung-Hoon et al. (2017) Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression. Xenotransplantation :
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Kim, Jaeyoung; Kim, Dong Hyun; Choi, Hyuk Jin et al. (2017) Anti-CD40 antibody-mediated costimulation blockade promotes long-term survival of deep-lamellar porcine corneal grafts in non-human primates. Xenotransplantation 24:
Azimzadeh, Agnes M; Zhang, Tianshu; Wu, Guosheng et al. (2017) Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys. Transplantation 101:63-73
Rife Magalis, Brittany; Nolan, David J; Autissier, Patrick et al. (2017) Insights into the Impact of CD8+ Immune Modulation on Human Immunodeficiency Virus Evolutionary Dynamics in Distinct Anatomical Compartments by Using Simian Immunodeficiency Virus-Infected Macaque Models of AIDS Progression. J Virol 91:

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