Despite the great importance of cardiovascular disease (CVD) as one of the leading causes of morbidity and mortality, research and training in this disease has been relatively neglected in Uganda. There is lack of good quality data on the epidemiology of CVD and on clinical outcomes and few on-site experts in CVD. This situation translates into low levels of awareness in the communities, poorer outcomes and sub-optimal primary care responses to CVDs. We propose to expand our highly successful research collaborations In infectious diseases to include CVD, with the goal of designing a program that will substantially improve the capacity for research and training in Uganda and to address the critical shortage of leaders in CVD. Using the community-based education, research and service (COBERS) sites in the programmatic award, training of medical students in CVD risk assessment and primary care will be supported. In addition, master's degree programs for residents and short term fellowships and PhD training for young faculty will be provided to develop clinical and research careers in CVD. Besides, research training in this program will be linked to a research project that will collect baseline epidemiological data. This MEPI program will be integrated within the existing framework of training at two major medical schools in Uganda namely Makerere University College of Health Sciences (MUCHS) and Mbarara University of Science and Technology to ensure its sustainability. These two medical schools are part of the MUCHS Programmatic application and will collaborate with other institutions including the Medical Research council in Uganda to support the community based CVD epidemiologic survey. Case Western University to provide visiting faculty and mentorship, and Yale University to provide short term fellowship programs for Ugandan residents and faculty. This proposal is in line with the government of Uganda Health Sector Strategic Plan that highlights building capacity for CVD prevention as one of its core priorities. By the end of this program, a critical mass of personnel will have been trained. The research environment for CVD will have been improved and this will likelv lead to substantial increase in publications and improve retention of the trained facultv.

Public Health Relevance

Despite the great importance of cardiovascular disease (CVD) as one of the leading causes of morbidity and mortality, research and training in this disease has been relatively neglected in Uganda. Improved in-country CVD expertise and better knowledge of the epidemiology of CVD will be critical to assist the Ministry of Health in establishing effective policies for the treatment and control of CVD and will improve outcomes.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Resource-Related Research Projects (R24)
Project #
5R24TW008861-05
Application #
8729400
Study Section
Special Emphasis Panel ()
Program Officer
Razak, Myat Htoo
Project Start
2010-09-27
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
$500,000
Indirect Cost
$30,593
Name
Makerere University
Department
Type
DUNS #
850536636
City
Kampala
State
Country
Uganda
Zip Code
7062
Gleason, Brigette; Mirembe, Grace; Namuyonga, Judith et al. (2016) Brief Report: Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda. J Acquir Immune Defic Syndr 71:196-9
Lugero, Charles; Kibirige, Davis; Kayima, James et al. (2016) Atrial fibrillation among the black population in a Ugandan tertiary hospital. Int J Gen Med 9:191-8
Namuyonga, Judith; Lubega, Sulaiman; Musiime, Victor et al. (2016) Cardiac Dysfunction Among Ugandan HIV-infected Children on Antiretroviral Therapy. Pediatr Infect Dis J 35:e85-8
Batte, Anthony; Lwabi, Peter; Lubega, Sulaiman et al. (2016) Prevalence of arrhythmias among children below 15 years of age with congenital heart diseases attending Mulago National Referral Hospital, Uganda. BMC Cardiovasc Disord 16:67
Kebba, Naomi; Mwambu, Tom; Oketcho, Michael et al. (2016) Chest closure without drainage after open patent ductus arteriosus ligation in Ugandan children: A non blinded randomized controlled trial. BMC Surg 16:69
Nankabirwa, Harriet; Kalyesubula, Robert; Ssinabulya, Isaac et al. (2016) A cross-sectional study of hyponatraemia among elderly patients with heart failure in Uganda. BMJ Open 6:e009775
Muddu, Martin; Mutebi, Edrisa; Mondo, Charles (2016) Prevalence, types and factors associated with echocardiographic abnormalities among newly diagnosed diabetic patients at Mulago Hospital. Afr Health Sci 16:183-93
Nakibuuka, Jane; Sajatovic, Martha; Nankabirwa, Joaniter et al. (2016) Effect of a 72 Hour Stroke Care Bundle on Early Outcomes after Acute Stroke: A Non Randomised Controlled Study. PLoS One 11:e0154333
Babua, Christopher; Kalyesubula, Robert; Okello, Emmy et al. (2015) Pattern and presentation of cardiac diseases among patients with chronic kidney disease attending a national referral hospital in Uganda: a cross sectional study. BMC Nephrol 16:126
Mayito, Jonathan; Mungoma, Michael; Kakande, Barbara et al. (2015) Angiotensin II status and sympathetic activation among hypertensive patients in Uganda: a cross-sectional study. BMC Res Notes 8:586

Showing the most recent 10 out of 28 publications