It is estimated that development and effective application of cancer prevention strategies could substantially reduce cancer deaths. There is a need to accelerate the discovery, development, and delivery of cancer prevention interventions by enhancing research efforts focused on risk assessment, systems biology, behavior modifications, environmental and policy influences, medical and nutritional approaches. To address this need, training and education for researchers, early in their careers, in issues relevant to cancer prevention research with a broad interdisciplinary approach is required. A Cancer Prevention Interdisciplinary education Program (CPIP) is proposed, building on the focus and expertise of cancer prevention interdisciplinary research at Purdue University. The central hypothesis is that development of an undergraduate and graduate interdisciplinary program in cancer prevention will: 1) increase interest in the pursuit of graduate studies and subsequent careers in cancer prevention research;2) provide exposure to all aspects of the field at a critical time to prepare students to better approach research problems, and 3) prepare these students for successful careers in cancer prevention research. These hypotheses will be tested by two specific aims: 1) Develop and test an interdisciplinary curriculum for undergraduates that will create a new pool of scientists who will effectively address research problems in cancer prevention;and 2) Develop and test an interdisciplinary curriculum for graduate students that will create a new pool of scientists who will effectively address research problems in cancer prevention. Both student populations will participate in a curriculum to introduce issues specific to cancer prevention research across broad interdisciplinary lines, participate in community-based service learning projects to address issues in cancer prevention and also complete mentored research projects with a cancer prevention focus. The interdisciplinary strengths of the research team and substantial institutional support for interdisciplinary research and this project, innovative learning projects and a campus wide focus on cancer prevention research makes Purdue University an ideal site to develop and test the proposed innovative curriculum. Development, testing and dissemination of this curriculum will enhance efforts in the cancer prevention research field nation wide. Subsequently, increasing the pool of scientists with an understanding of the interdisciplinary issues in cancer prevention research will greatly enhance the progress to develop cancer prevention strategies and reduce cancer deaths, consistent with the mission of the National Cancer Institute.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA128770-05
Application #
8320011
Study Section
Subcommittee G - Education (NCI)
Program Officer
Korczak, Jeannette F
Project Start
2008-09-26
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$304,750
Indirect Cost
$9,871
Name
Purdue University
Department
Nutrition
Type
Other Domestic Higher Education
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Wilmanski, Tomasz; Buhman, Kimberly; Donkin, Shawn S et al. (2016) 1α,25-dihydroxyvitamin D inhibits de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells through down-regulation of pyruvate carboxylase. J Nutr Biochem 40:194-200
Zhou, Xuanzhu; Zheng, Wei; Nagana Gowda, G A et al. (2016) 1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell. J Steroid Biochem Mol Biol 163:147-56
Li, J; Gu, D; Lee, S S-Y et al. (2016) Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene 35:6378-6388
Wang, Fa; Johnson, Robert L; Snyder, Paul W et al. (2016) An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research. Dig Dis Sci 61:1069-79
Wilmanski, Tomasz; Barnard, Alle; Parikh, Mukti R et al. (2016) 1α,25-Dihydroxyvitamin D Inhibits the Metastatic Capability of MCF10CA1a and MDA-MB-231 Cells in an In Vitro Model of Breast to Bone Metastasis. Nutr Cancer 68:1202-9
Chowdhury, Basudev; Seetharam, Arun; Wang, Zhiping et al. (2016) A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells. PLoS One 11:e0147514
DeWitt, Marsha; Johnson, Robert L; Snyder, Paul et al. (2015) The effect of 1,25 dihydroxyvitamin D3 treatment on the mRNA levels of β catenin target genes in mice with colonic inactivation of both APC alleles. J Steroid Biochem Mol Biol 148:103-10
Chowdhury, Basudev; McGovern, Andrew; Cui, Yi et al. (2015) The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells. Sci Rep 5:9281
Lipchik, Andrew M; Perez, Minervo; Bolton, Scott et al. (2015) KINATEST-ID: a pipeline to develop phosphorylation-dependent terbium sensitizing kinase assays. J Am Chem Soc 137:2484-94
Zheng, Wei; Tayyari, Fariba; Gowda, G A Nagana et al. (2015) Altered glucose metabolism in Harvey-ras transformed MCF10A cells. Mol Carcinog 54:111-20

Showing the most recent 10 out of 52 publications