It is estimated that development and effective application of cancer prevention strategies could substantially reduce cancer deaths. There is a need to accelerate the discovery, development, and delivery of cancer prevention interventions by enhancing research efforts focused on risk assessment, systems biology, behavior modifications, environmental and policy influences, medical and nutritional approaches. To address this need, training and education for researchers, early in their careers, in issues relevant to cancer prevention research with a broad interdisciplinary approach is required. A Cancer Prevention Interdisciplinary education Program (CPIP) is proposed, building on the focus and expertise of cancer prevention interdisciplinary research at Purdue University. The central hypothesis is that development of an undergraduate and graduate interdisciplinary program in cancer prevention will: 1) increase interest in the pursuit of graduate studies and subsequent careers in cancer prevention research;2) provide exposure to all aspects of the field at a critical time to prepare students to better approach research problems, and 3) prepare these students for successful careers in cancer prevention research. These hypotheses will be tested by two specific aims: 1) Develop and test an interdisciplinary curriculum for undergraduates that will create a new pool of scientists who will effectively address research problems in cancer prevention;and 2) Develop and test an interdisciplinary curriculum for graduate students that will create a new pool of scientists who will effectively address research problems in cancer prevention. Both student populations will participate in a curriculum to introduce issues specific to cancer prevention research across broad interdisciplinary lines, participate in community-based service learning projects to address issues in cancer prevention and also complete mentored research projects with a cancer prevention focus. The interdisciplinary strengths of the research team and substantial institutional support for interdisciplinary research and this project, innovative learning projects and a campus wide focus on cancer prevention research makes Purdue University an ideal site to develop and test the proposed innovative curriculum. Development, testing and dissemination of this curriculum will enhance efforts in the cancer prevention research field nation wide. Subsequently, increasing the pool of scientists with an understanding of the interdisciplinary issues in cancer prevention research will greatly enhance the progress to develop cancer prevention strategies and reduce cancer deaths, consistent with the mission of the National Cancer Institute.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA128770-05
Application #
8320011
Study Section
Subcommittee G - Education (NCI)
Program Officer
Korczak, Jeannette F
Project Start
2008-09-26
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$304,750
Indirect Cost
$9,871
Name
Purdue University
Department
Nutrition
Type
Other Domestic Higher Education
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
King, Andy J; Jensen, Jakob D; Guntzviller, Lisa M et al. (2018) Ethnic newspapers and low-income Spanish-speaking adults: influence of news consumption and health motivation on cancer prevention behaviors. Ethn Health 23:410-424
Shinde, Aparna; Wilmanski, Tomasz; Chen, Hao et al. (2018) Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer. Breast Cancer Res 20:76
Wang, Fa; Johnson, Robert L; DeSmet, Marsha L et al. (2017) Vitamin D Receptor-Dependent Signaling Protects Mice From Dextran Sulfate Sodium-Induced Colitis. Endocrinology 158:1951-1963
Wilmanski, Tomasz; Buhman, Kimberly; Donkin, Shawn S et al. (2017) 1?,25-dihydroxyvitamin D inhibits de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells through down-regulation of pyruvate carboxylase. J Nutr Biochem 40:194-200
Carcioppolo, Nick; Orrego Dunleavy, Victoria; Yang, Qinghua (2017) How Do Perceived Descriptive Norms Influence Indoor Tanning Intentions? An Application of the Theory of Normative Social Behavior. Health Commun 32:230-239
DeSmet, Marsha L; Fleet, James C (2017) Constitutively active RAS signaling reduces 1,25 dihydroxyvitamin D-mediated gene transcription in intestinal epithelial cells by reducing vitamin D receptor expression. J Steroid Biochem Mol Biol 173:194-201
Wilmanski, Tomasz; Barnard, Alle; Parikh, Mukti R et al. (2016) 1?,25-Dihydroxyvitamin D Inhibits the Metastatic Capability of MCF10CA1a and MDA-MB-231 Cells in an In Vitro Model of Breast to Bone Metastasis. Nutr Cancer 68:1202-9
Zhou, Xuanzhu; Zheng, Wei; Nagana Gowda, G A et al. (2016) 1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell. J Steroid Biochem Mol Biol 163:147-56
Li, J; Gu, D; Lee, S S-Y et al. (2016) Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene 35:6378-6388
Wang, Fa; Johnson, Robert L; Snyder, Paul W et al. (2016) An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research. Dig Dis Sci 61:1069-79

Showing the most recent 10 out of 57 publications