This R25 application proposes to train psychiatry residents to conduct high-quality cutting-edge research, develop outstanding scientific expertise, sustain life-long engagement in research, and have successful careers as research-oriented physician-scientists in psychiatry/neuroscience. The critical shortage of physician-scientists in our field poses an immediate and severe threat to understanding and treating mental illness. We are well-positioned to offer intensive research training to our residents at a critical juncture in their careers. Our training program will increase the number of psychiatrists who conduct translational, basic, or clinical research that fulfills the objectives of the NIMH strategic plan.
We aim to: 1) attract and train outstanding psychiatry residents to become future physician-scientists in psychiatry/neuroscience;2) provide protected research time from PGY1 through PGY4 for a mentored research training experience in translational, basic, or clinical research;3) provide protected time to participate in an individualized research-focused didactic curriculum (seminars and courses) in a rich multidisciplinary environment;and 4) provide career development skills needed for successful physician-scientist careers. Residents will participate from PGY1 through PGY4;a total of 8 residents (2 per PG year) will participate at any one time. Metrics of success will include publications, presentations, grant pilot data, research funding, and transitioning to post-residency research fellowships, grant funding, and/or academic faculty positions. The research education program will be integrated into Brown's adult psychiatry residency program and led by a team with extensive experience in research, teaching, and mentorship. We will leverage the exceptional research education opportunities available at Brown, including those sponsored by the Psychiatry Department's 6 T32 grants, the Brown Institute for Brain Science, and Brown's Neuroscience Department. Brown University's General Psychiatry Residency has supported research training and has recently developed a successful formal Resident Research Training Pilot Program, which offers protected time during PGY1 and PGY2. However, protected research time in PGY3 and PGY4 is insufficient to provide our most outstanding research-focused residents with more intensive research training. An R25 grant, in combination with additional institutional resources, will serve an important unmet need by increasing protected research time from the current 10% to 25% in PGY3 and from less than 20% to 80% in PGY4. Brown is exceptionally well-poised to take our resident research training to the next level of excellence. An R25 will provide essential support to substantially enhance our residents'research training experience. We offer an outstanding research training environment at a time that is particularly exciting for psychiatry and brain science at Brown, given institutional prioritization of these areas, our cross-disciplinary collaboration, and our faculty's productivity and longstanding commitment to mentoring the next generation of physician-scientists. !

Public Health Relevance

The critical shortage of psychiatric physician-scientists poses an immediate and severe threat to understanding and treating mental illness. The proposed research education program will provide essential support to substantially and meaningfully enhance research training of our most talented and committed psychiatry residents. Our goal is to advance understanding and treatment of mental illness by encouraging sustained interest in a research career and training the next generation of translational, basic, and clinical physician- scientists. !

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Education Projects (R25)
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Special Emphasis Panel (ZMH1)
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Chavez, Mark
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Brown University
Schools of Medicine
United States
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Gwynette, McLeod Frampton; Morriss, Danielle; Warren, Nancy et al. (2017) Social Skills Training for Adolescents With Autism Spectrum Disorder Using Facebook (Project Rex Connect): A Survey Study. JMIR Ment Health 4:e4
Capurso, Noah A; Ross, David A (2017) As Hopes Have Flown Before: Toward the Rational Design of Treatments for Alcohol Use Disorder. Biol Psychiatry 81:e79-e81
Parent, Justin; Parade, Stephanie H; Laumann, Laura E et al. (2017) Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment. Dev Psychopathol 29:1635-1648
Kinasz, Kathryn R; Ross, David A; Cooper, Joseph J (2017) Eat to Live or Live to Eat? The Neurobiology of Appetite Regulation. Biol Psychiatry 81:e73-e75
Ho, Pochu; Ross, David A (2017) More Than a Gut Feeling: The Implications of the Gut Microbiota in Psychiatry. Biol Psychiatry 81:e35-e37
Dwyer, Jennifer B; Ross, David A (2017) The Nature of Nurture: How Developmental Experiences Program Adult Stress Circuitry. Biol Psychiatry 81:e57-e59
Bertocci, M A; Bebko, G; Versace, A et al. (2017) Reward-related neural activity and structure predict future substance use in dysregulated youth. Psychol Med 47:1357-1369
McCann, Ruth F; Ross, David A (2017) A Fragile Balance: Dendritic Spines, Learning, and Memory. Biol Psychiatry 82:e11-e13
Ridout, K K; Levandowski, M; Ridout, S J et al. (2017) Early life adversity and telomere length: a meta-analysis. Mol Psychiatry :
De Aquino, Joao P; Ross, David A (2017) Kraepelin's Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biol Psychiatry 82:e71-e74

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