This is a competitive continuation application of our Brown University R25 program ?Promoting Research Training During Psychiatry Residency.? Exciting advances in basic and clinical psychiatry/neuroscience and genomics hold the promise of revealing the causes and potential new treatments for mental illnesses. However, a critical shortage of physician-scientists poses a threat to our ability to advance and translate discoveries from basic science into effective prevention and treatment approaches. The overarching goal of our Research Training Program (RTP) is to train the next generation of psychiatry residents to design and conduct rigorous, innovative and impactful research and develop successful careers as independently funded research-oriented physician-scientists in psychiatry/neuroscience. In the first five years of this program we have achieved our recruitment and training goals, and our residents have been remarkably successful with their research and early career development. Conducting innovative and rigorous research, our RTP residents have presented and published their findings widely and in top-tier journals. RTP residents have successfully competed for travel and poster awards, and their research projects have been funded by numerous national and local research funding awards. Our program combines an intensive longitudinal mentored research experience with an individualized research didactic curriculum and career development activities in a rich, multidisciplinary environment at Brown University. The cohesive program leadership team and Advisory Committee balance research and clinical training, monitor research and career development progress, and solicit feedback for program improvement. This application seeks to carry out the following aims: 1) Continue to recruit and train highly-qualified psychiatry residents to develop independent research careers, and 2) Build upon our existing successful program to further support resident research and career development with new and innovative components. Continuation of funding for this program would enable us to train 10 research- focused residents (two per year) over the next 5 years, thereby expanding the number of highly trained physician scientists in research domains central to the NIMH mission. The outstanding research training environment in psychiatry and brain science at Brown, characterized by internationally recognized, externally funded, innovative research programs and investigators, cross-disciplinary collaborations, and exceptionally well-qualified and dedicated mentors, makes our psychiatry residency an ideal environment in which to train the next generation of physician-scientists in psychiatry and neuroscience.

Public Health Relevance

Recent exciting developments in psychiatry and neuroscience hold great promise for our understanding of the causes and treatments for mental illness. However, a critical shortage of physician-scientists limits our ability to advance this science and translate discoveries into effective prevention and treatment strategies. This application seeks to continue support for a psychiatry residency research training program that aims to increase the number of physician-scientists conducting innovative and rigorous research on the causes and treatment of psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Education Projects (R25)
Project #
3R25MH101076-06A1S1
Application #
10218833
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Chavez, Mark
Project Start
2013-09-06
Project End
2025-06-30
Budget Start
2020-07-16
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Brown University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Levinsohn, Erik A; Ross, David A (2018) Out of the Cave, Into the Light? Modeling Mental Illness With Organoids. Biol Psychiatry 83:e43-e44
Wright, Carrie; Ross, David A; Weinberger, Daniel R (2018) Small RNAs May Answer Big Questions in Mental Illness. Biol Psychiatry 83:e1-e3
Radhakrishnan, Rajiv; Ross, David A (2018) From ""Azalla"" to Anandamide: Distilling the Therapeutic Potential of Cannabinoids. Biol Psychiatry 83:e27-e29
Novick, Andrew M; Ross, David A (2018) Changing the Way We Think About (and With) Antidepressants. Biol Psychiatry 84:e27-e28
Zick, Jennifer L; Blackman, Rachael K; Crowe, David A et al. (2018) Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia. Neuron 98:1243-1255.e5
Ridout, K K; Levandowski, M; Ridout, S J et al. (2018) Early life adversity and telomere length: a meta-analysis. Mol Psychiatry 23:858-871
Mariano, Timothy Y; Burgess, Frederick W; Bowker, Marguerite et al. (2018) Transcranial Direct Current Stimulation for Affective Symptoms and Functioning in Chronic Low Back Pain: A Pilot Double-Blinded, Randomized, Placebo-Controlled Trial. Pain Med :
Petrosino, Nicholas J; Zandvakili, Amin; Carpenter, Linda L et al. (2018) Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation. Front Psychiatry 9:605
Moreno-De-Luca, Daniel; Ross, Michael E; Ross, David A (2018) Leveraging the Power of Genetics to Bring Precision Medicine to Psychiatry: Too Little of a Good Thing? Biol Psychiatry 83:e45-e46
Aoun, E G; Jimenez, V A; Vendruscolo, L F et al. (2018) A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Mol Psychiatry 23:1466-1473

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