III. Abstract of Research Plan for Extension Period (5 years) 1. To examine the role of co-repressors, e.g., HDAC, Sin3A, in menin-mediated inhibition of gastrin 2. To examine the role of somatostatin in regulation of co-repressors 3. To determine the role of somatostatin and menin in the regulation of p27 and cell proliferation. Role of MLL. Are duodenal gastrinomas of myeloid origin?
Relevance to publish health include furthering our understanding of peptic ulcer disease, neuroendocrine transformation and the molecular basis underlying the effects of SOM analogs used to treat neuroendocrine disorders.
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|Veniaminova, Natalia A; Hayes, Michael M; Varney, Jessica M et al. (2012) Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol 303:G752-64|
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|Mensah-Osman, Edith J; Veniaminova, Natalia A; Merchant, Juanita L (2011) Menin and JunD regulate gastrin gene expression through proximal DNA elements. Am J Physiol Gastrointest Liver Physiol 301:G783-90|
|Tucker, Tamara P; Gray, Brian M; Eaton, Kathyrn A et al. (2010) Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements. Helicobacter 15:438-48|
|Zavros, Yana; Mesiwala, Nisreen; Waghray, Meghna et al. (2010) Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis. World J Gastrointest Pathophysiol 1:154-65|
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