III. Abstract of Research Plan for Extension Period (5 years) 1. To examine the role of co-repressors, e.g., HDAC, Sin3A, in menin-mediated inhibition of gastrin 2. To examine the role of somatostatin in regulation of co-repressors 3. To determine the role of somatostatin and menin in the regulation of p27 and cell proliferation. Role of MLL. Are duodenal gastrinomas of myeloid origin?

Public Health Relevance

Relevance to publish health include furthering our understanding of peptic ulcer disease, neuroendocrine transformation and the molecular basis underlying the effects of SOM analogs used to treat neuroendocrine disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK045729-20
Application #
8523835
Study Section
Special Emphasis Panel (NSS)
Program Officer
Serrano, Jose
Project Start
1993-09-01
Project End
2017-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
20
Fiscal Year
2013
Total Cost
$345,793
Indirect Cost
$123,418
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Huang, Jing; Gurung, Buddha; Wan, Bingbing et al. (2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482:542-6
Mensah-Osman, Edith J; Veniaminova, Natalia A; Merchant, Juanita L (2011) Menin and JunD regulate gastrin gene expression through proximal DNA elements. Am J Physiol Gastrointest Liver Physiol 301:G783-90
Mensah-Osman, Edith; Labut, Ed; Zavros, Yana et al. (2008) Regulated expression of the human gastrin gene in mice. Regul Pept 151:115-22
Mensah-Osman, Edith; Zavros, Yana; Merchant, Juanita L (2008) Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol Gastrointest Liver Physiol 295:G843-54
Ofori-Darko, E; Zavros, Y; Rieder, G et al. (2000) An OmpA-like protein from Acinetobacter spp. stimulates gastrin and interleukin-8 promoters. Infect Immun 68:3657-66
Merchant, J L; Iyer, G R; Taylor, B R et al. (1996) ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter. Mol Cell Biol 16:6644-53