of Research Plan for Extension Period (5 years)1. To examine the role of co-repressors, e.g., HDAC, Sin3A, in menin-mediated inhibition of gastrin2. To examine the role of somatostatin in regulation of co-repressors3. To determine the role of somatostatin and menin in the regulation of p27 and cell proliferation. Role ofMLL. Are duodenal gastrinomas of myeloid origin?

Public Health Relevance

Relevance to publish health include furthering our understanding of peptic ulcer disease, neuroendocrinetransformation and the molecular basis underlying the effects of SOM analogs used to treat neuroendocrinedisorders.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Method to Extend Research in Time (MERIT) Award (R37)
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Special Emphasis Panel (NSS)
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Serrano, Jose
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
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Wang, Zhen; Ocadiz-Ruiz, Ramon; Sundaresan, Sinju et al. (2018) Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse. J Vis Exp :
Sundaresan, Sinju; Kang, Anthony J; Merchant, Juanita L (2017) Pathophysiology of Gastric NETs: Role of Gastrin and Menin. Curr Gastroenterol Rep 19:32
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Huang, Jing; Gurung, Buddha; Wan, Bingbing et al. (2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482:542-6
Saqui-Salces, Milena; Cov├ęs-Datson, Evelyn; Veniaminova, Natalia A et al. (2012) Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One 7:e48039
Berndt, Bradford E; Zhang, Min; Owyang, Stephanie Y et al. (2012) Butyrate increases IL-23 production by stimulated dendritic cells. Am J Physiol Gastrointest Liver Physiol 303:G1384-92
Saqui-Salces, Milena; Dowdle, William E; Reiter, Jeremy F et al. (2012) A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB J 26:3127-39

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