In the last funding period, we have completed a series of critical studies to examine the effect of lithotripter beam size on stone comminution, to compare the characteristics of electromagnetic (EM) vs. electrohydraulic (EH) shock wave lithotripters both in vitro and in vivo, and to develop technical innovations that can be upgraded on a modern EM lithotripter. A new line of investigation is proposed in this renewal application, which is motivated by the recognition that over the past decade, the landscape in shock wave lithotripsy (SWL) has shifted from EH to EM technology because of the longevity, stability and large dynamic range of pressure output offered by EM lithotripters. However, despite these advantages the performance of EM lithotripters (including the 3rd generation machines) has not reached the gold standard that was established by the original Dornier HM-3 (EH) lithotripter more than 25 years ago. Therefore, there is a strong desire from both lithotripter manufacturers and practicing urologists to improve the design and performance of EM lithotripters. We propose the following specific aims to develop innovative SWL technologies to be integrated in a modern EM lithotripter.
Aim 1. Re-engineering the acoustic lens design in an electromagnetic shock wave lithotripter to produce an idealized pressure waveform profile with a broad beam size Aim 2. Generating a steerable and non-axisymmetric acoustic field by an electromagnetic shock wave source for better coverage of the respiratory motion of kidney stones and lateral spreading of residual fragments in vivo Aim 3. Developing co-axial microsecond tandem pulse technology in an electromagnetic shock wave lithotripter for improved stone comminution Aim 4. Optimizing treatment strategy employed during SWL to maximize stone comminution efficiency with minimal tissue injury We have assembled a multidisciplinary research team with diverse expertise in engineering, materials science, applied mathematics, and urologic surgery. We will also collaborate closely with Siemens for lithotripter design upgrade and system integration. It is anticipated that the synergistic interaction between our multidisciplinary research team and Siemens will lead to a rapid translation of basic research in academic laboratories to the next-generation commercial shock wave lithotripters that can benefit all stone patients.
In recent years, the prevalence of kidney stones has increased in parallel with the blistering epidemics of obesity, type 2 diabetes mellitus, and other phenotypes commonly encountered in the metabolic syndrome, and the direct expenditures for treatment of stone disease in the U.S. exceed $2 billion annually, second only to urinary tract infection among urologic diseases. Because of its non-invasive nature, ease of use, and high reimbursement rate for urologists, shock wave lithotripsy (SWL) remains a first-line therapy for the management of most kidney stones, yet the current models of clinical lithotripters have become less effective in disintegrating kidney stones, but often have higher propensity to produce tissue injury than the first- generation Dornier HM-3 lithotripter. We will carry out a multidisciplinary investigation with synergistic collaborations between academic laboratories and the medical device industry (i.e., Siemens) to develop the next-generation shock wave lithotripter with significantly improved performance and safety features that will benefit all patients that require surgical removal of kidney stones.
|Zhang, Ying; Nault, Isaac; Mitran, Sorin et al. (2016) Effects of Stone Size on the Comminution Process and Efficiency in Shock Wave Lithotripsy. Ultrasound Med Biol 42:2662-2675|
|Yuan, Fang; Yang, Chen; Zhong, Pei (2015) Cell membrane deformation and bioeffects produced by tandem bubble-induced jetting flow. Proc Natl Acad Sci U S A 112:E7039-47|
|Neisius, Andreas; Smith, Nathan B; Sankin, Georgy et al. (2014) Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter. Proc Natl Acad Sci U S A 111:E1167-75|
|Hsiao, C-T; Choi, J-K; Singh, S et al. (2013) Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications. J Fluid Mech 716:|
|Smith, Nathan B; Zhong, Pei (2013) A heuristic model of stone comminution in shock wave lithotripsy. J Acoust Soc Am 134:1548-58|
|Fovargue, Daniel E; Mitran, Sorin; Smith, Nathan B et al. (2013) Experimentally validated multiphysics computational model of focusing and shock wave formation in an electromagnetic lithotripter. J Acoust Soc Am 134:1598-609|
|Mancini, John G; Neisius, Andreas; Smith, Nathan et al. (2013) Assessment of a modified acoustic lens for electromagnetic shock wave lithotripters in a Swine model. J Urol 190:1096-101|
|Lautz, Jaclyn; Sankin, Georgy; Zhong, Pei (2013) Turbulent water coupling in shock wave lithotripsy. Phys Med Biol 58:735-48|
|Smith, N; Sankin, G N; Simmons, W N et al. (2012) A comparison of light spot hydrophone and fiber optic probe hydrophone for lithotripter field characterization. Rev Sci Instrum 83:014301|
|Zhou, Yufeng; Qin, Jun; Zhong, Pei (2012) Characteristics of the secondary bubble cluster produced by an electrohydraulic shock wave lithotripter. Ultrasound Med Biol 38:601-10|
Showing the most recent 10 out of 19 publications