Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM033309-23
Application #
6874933
Study Section
Special Emphasis Panel (NSS)
Program Officer
Preusch, Peter C
Project Start
1989-12-01
Project End
2006-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
23
Fiscal Year
2005
Total Cost
$455,751
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Engineering
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Bailis, Julie M; Weidmann, Alyson G; Mariano, Natalie F et al. (2017) Rhodium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells. Proc Natl Acad Sci U S A 114:6948-6953
Boynton, Adam N; Marcélis, Lionel; McConnell, Anna J et al. (2017) A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites. Inorg Chem 56:8381-8389
Boynton, Adam N; Marcélis, Lionel; Barton, Jacqueline K (2016) [Ru(Me4phen)2dppz](2+), a Light Switch for DNA Mismatches. J Am Chem Soc 138:5020-3
Boyle, Kelsey M; Barton, Jacqueline K (2016) Targeting DNA Mismatches with Rhodium Metalloinsertors. Inorganica Chim Acta 452:3-11
Weidmann, Alyson G; Barton, Jacqueline K (2015) A monofunctional platinum complex coordinated to a rhodium metalloinsertor selectively binds mismatched DNA in the minor groove. Inorg Chem 54:9626-36
Komor, Alexis C; Barton, Jacqueline K (2014) An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency. J Am Chem Soc 136:14160-72
Weidmann, Alyson G; Barton, Jacqueline K (2014) Construction and application of a Rh-Pt DNA metalloinsertor conjugate. Inorg Chem 53:7812-4
Bailis, Julie M; Gordon, Marcia L; Gurgel, Jesse L et al. (2013) An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. PLoS One 8:e78726
Komor, Alexis C; Barton, Jacqueline K (2013) The path for metal complexes to a DNA target. Chem Commun (Camb) 49:3617-30
McConnell, Anna J; Song, Hang; Barton, Jacqueline K (2013) Luminescence of [Ru(bpy)2(dppz)]2+ bound to RNA mismatches. Inorg Chem 52:10131-6

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