Metal Probes and Drug Binding to DNA

Barton, Jacqueline K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37GM033309-23
• Application #: 6874933
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Preusch, Peter C
• Project Start: 1989-12-01
• Project End: 2006-03-31
• Budget Start: 2005-04-01
• Budget End: 2006-03-31
• Support Year: 23
• Fiscal Year: 2005
• Total Cost: $455,751

Institution

• Name: California Institute of Technology
• Type: Schools of Engineering
• DUNS #: 009584210
• City: Pasadena
• State: CA
• Country: United States
• Zip Code: 91125

Publications

Boyle, Kelsey M; Barton, Jacqueline K (2018) A Family of Rhodium Complexes with Selective Toxicity toward Mismatch Repair-Deficient Cancers. J Am Chem Soc 140:5612-5624

Bailis, Julie M; Weidmann, Alyson G; Mariano, Natalie F et al. (2017) Rhodium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells. Proc Natl Acad Sci U S A 114:6948-6953

Boynton, Adam N; Marcélis, Lionel; McConnell, Anna J et al. (2017) A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites. Inorg Chem 56:8381-8389

Boyle, Kelsey M; Barton, Jacqueline K (2016) Targeting DNA Mismatches with Rhodium Metalloinsertors. Inorganica Chim Acta 452:3-11

Boynton, Adam N; Marcélis, Lionel; Barton, Jacqueline K (2016) [Ru(Me4phen)2dppz](2+), a Light Switch for DNA Mismatches. J Am Chem Soc 138:5020-3

Weidmann, Alyson G; Barton, Jacqueline K (2015) A monofunctional platinum complex coordinated to a rhodium metalloinsertor selectively binds mismatched DNA in the minor groove. Inorg Chem 54:9626-36

Komor, Alexis C; Barton, Jacqueline K (2014) An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency. J Am Chem Soc 136:14160-72

Weidmann, Alyson G; Barton, Jacqueline K (2014) Construction and application of a Rh-Pt DNA metalloinsertor conjugate. Inorg Chem 53:7812-4

Bailis, Julie M; Gordon, Marcia L; Gurgel, Jesse L et al. (2013) An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. PLoS One 8:e78726

McConnell, Anna J; Song, Hang; Barton, Jacqueline K (2013) Luminescence of [Ru(bpy)2(dppz)]2+ bound to RNA mismatches. Inorg Chem 52:10131-6