Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37HL009610-36
Application #
2898672
Study Section
Special Emphasis Panel (NSS)
Project Start
1965-06-01
Project End
2005-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
36
Fiscal Year
2000
Total Cost
$705,714
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Jones, Ryan D; Repa, Joyce J; Russell, David W et al. (2012) Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid. Am J Physiol Gastrointest Liver Physiol 303:G263-74
Hashi, Craig K; Glickman, Marc H (2011) Preclinical results of a prosthetic, early-stick graft with functional endothelium. J Vasc Access 12:231-8
Turley, Stephen D; Valasek, Mark A; Repa, Joyce J et al. (2010) Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol 299:G1012-22
Valasek, Mark A; Repa, Joyce J; Quan, Gang et al. (2008) Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am J Physiol Gastrointest Liver Physiol 295:G813-22
Xie, Chonglun; Richardson, James A; Turley, Stephen D et al. (2006) Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein. J Lipid Res 47:953-63
Beltroy, Eduardo P; Richardson, James A; Horton, Jay D et al. (2005) Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease. Hepatology 42:886-93
Garver, William S; Xie, Chonglun; Repa, Joyce J et al. (2005) Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse. J Lipid Res 46:1745-54
Repa, Joyce J; Turley, Stephen D; Quan, Gang et al. (2005) Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption. J Lipid Res 46:779-89
Li, Hao; Repa, Joyce J; Valasek, Mark A et al. (2005) Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol 64:323-33
Dietschy, John M; Turley, Stephen D (2004) Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 45:1375-97

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