r ???????????---__-_.-__?_ ?__ ?-__ ?_.. ???-? ?-- ??. ?_ | 'Heart failure is a syndrome of profound clinical and public health importance. Heart failure (HF) is estimated to contribute to' '?nearly 1 million hospitalizations and approximately 250,000 deaths annually in the U.S. The number of new cases of HF in the! [U.S. is estimated to exceed 400,000 annually. Though reliableestimates of the magnitude, incidence, and mortalityof HF remain! ]sorely lacking, HF is associated with a grim prognosis. However, little recent data exists, particularly from a community-wide! [perspective, to determine whether the incidence or survival associated with HF, and the management of this clinical syndrome,! |has changed over time. This study proposes to examine temporal trends (1995 and 2000) in the incidence rates of HF, its] |therapeutic management, and changes over time in the hospital and long-term survival of patients with HF from a multi-hospital [ 'population-based perspective. The study will take place in residents of the Worcester (MA) metropolitan area (1990 census =' 1437,000) and will examine changes over time in these and additional outcomes for patients with validated HF during 1995 and' 12000. Complimenting the hospital surveillance of HF, newly diagnosed cases of HF occurring in members of the largest HMO in! [Central Massachusetts during 1995 and 2000 will be identified and monitored over time. The proposed project will build on the! [investigators'clinical and epidemiological experience and on data collection efforts and methodologies used in the ongoing] [community-wide study of coronary heart disease in greater Worcester residents. To accomplish the study objectives, the medical] [records of residents of the Worcester metropolitan area hospitalized with a discharge diagnosis of HF and related diagnostic] """"""""rubrics will be individually reviewed and validated according to pre-established diagnostic criteria. The use of traditional criteria' ifor HF as well as development of new criteria for the epidemiological study of HF will be an important focus of this observational' [study. Records for additional hospitalizations and death certificates will be reviewed to examine trends in long-term survival of] [discharged hospital patients through the year 2005. The results of this study will provide much needed information aboutthe] [epidemiology of HF from a more generalizable population-based perspective. Information would be provided about the clinical', [and descriptive epidemiology of this prevalent and disabling condition in men and women and individualsof different age groups. [ [The proposed surveillance system will provide insights and guidance to public health and clinical efforts of HF and in monitoring; 'trends in this newly emerging chronic disease. ' [

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Method to Extend Research in Time (MERIT) Award (R37)
Project #
Application #
Study Section
Special Emphasis Panel (NSS)
Program Officer
Ni, Hanyu
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Massachusetts Medical School Worcester
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Darling, Chad E; Sun, Jiaoyuan Elisabeth; Goldberg, Jordan et al. (2017) A Historical Perspective on Presentations of Hypertensive Acute Heart Failure. J Cardiovasc Dis Diagn 5:
Zacharias, Michael; Joffe, Samuel; Konadu, Elizabeth et al. (2016) Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients. Int J Cardiol 202:918-21
Fisher, Kimberly A; Stefan, Mihaela S; Darling, Chad et al. (2015) Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study. Chest 147:637-645
Coles, Andrew H; Tisminetzky, Mayra; Yarzebski, Jorge et al. (2015) Magnitude of and Prognostic Factors Associated With 1-Year Mortality After Hospital Discharge for Acute Decompensated Heart Failure Based on Ejection Fraction Findings. J Am Heart Assoc 4:
Coles, Andrew H; Fisher, Kimberly; Darling, Chad et al. (2014) Long-term survival for patients with acute decompensated heart failure according to ejection fraction findings. Am J Cardiol 114:862-8
Mick, Eric; McManus, David D; Goldberg, Robert J (2013) Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults. Eur Neuropsychopharmacol 23:534-41
McManus, David D; Saczynski, Jane S; Lessard, Darleen et al. (2013) Recent trends in the incidence, treatment, and prognosis of patients with heart failure and atrial fibrillation (the Worcester Heart Failure Study). Am J Cardiol 111:1460-5
Joffe, Samuel W; Webster, Kristy; McManus, David D et al. (2013) Improved survival after heart failure: a community-based perspective. J Am Heart Assoc 2:e000053
Goldberg, Robert J; McManus, David D; Allison, Jeroan (2013) Greater knowledge and appreciation of commonly-used research study designs. Am J Med 126:169.e1-8
Waring, Molly E; Saczynski, Jane S; McManus, David et al. (2011) Weight and mortality following heart failure hospitalization among diabetic patients. Am J Med 124:834-40

Showing the most recent 10 out of 22 publications