The broad objective of this application is to identify neural mechanisms that cause migraineurs to seek sanctuary in the dark during attacks in effort to escape what they describe as my head hurts more and I feel worse when I am exposed to light. The long-term objectives are to identify the impact of light on sensory, affective and autonomic neurological functions during migraine (human study), and discover the neural pathways through which lights alter these functions (animal study). Leading up to this grant proposal are years of listening to patients' testimonies which taught us that exposure to different kind of lights can trigger different symptoms in migraineurs with normal eyesight as compared to blind and color-blind migraineurs. Based on what we heard, we postulated that exacerbation of headache by light is one of many reasons why migraineus seek the dark during migraine and that different colors of lights have the capacity to trigger different neurological symptoms. Mechanistically, we hypothesized that during migraine, activity of neurons in brain regions that mediate different aspects of sensory, emotional, and autonomic responses to pain is modulated by both headache and light through signals transmitted to them from the spinal trigeminal nucleus and the optic nerve. In the clinical study, we will determine the effects of different colos of light on the intensity of migraine headache and its many associated symptoms. Two groups of migraineurs (normal eyesight and visually-impaired) and a control group will be expose to different intensities of white, blue, green, yellow and red lights (delivered through an FDA-approved photic stimulator) when they are pain-free and during an attack. Data analysis and interpretation will include strength of electroretinography and visual evoked potential signals (waveforms) as well as documentation of sensory, affective and physiological changes. In the animal study, we will determine whether neurons that play a role in the neurological symptoms that are altered by light in patients receive direct input from the retina and brain areas involved in the transmission of migraine headache. These studies will combine psychophysical observations in human subjects with tract-tracing, immunohistochemical, molecular and physiological techniques in animals.
Photophobia often renders migraineurs dysfunctional as they are force to seek dark environment. The proposed research holds the key to the development of novel therapeutic strategies for preventing photophobia during migraine. The findings are also likely to advance our understanding of photophobia in individuals diagnosed with different types of retinal degenerative diseases, thus leading us a step closer to alleviating it.
|Melo-Carrillo, Agustin; Noseda, Rodrigo; Nir, Rony-Reuven et al. (2017) Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci 37:7149-7163|
|Becerra, Lino; Bishop, James; Barmettler, Gabi et al. (2017) Brain network alterations in the inflammatory soup animal model of migraine. Brain Res 1660:36-46|
|Noseda, Rodrigo; Borsook, David; Burstein, Rami (2017) Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache 57 Suppl 2:97-111|
|Noseda, Rodrigo; Lee, Alice J; Nir, Rony-Reuven et al. (2017) Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A 114:E5683-E5692|
|Melo-Carrillo, Agustin; Strassman, Andrew M; Nir, Rony-Reuven et al. (2017) Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (A?) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci 37:10587-10596|
|Schain, Aaron J; Melo-Carrillo, Agustin; Strassman, Andrew M et al. (2017) Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache. J Neurosci 37:2904-2915|
|Perry, Carlton J; Blake, Pamela; Buettner, Catherine et al. (2016) Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache. Ann Neurol 79:1000-13|
|Noseda, Rodrigo; Bernstein, Carolyn A; Nir, Rony-Reuven et al. (2016) Migraine photophobia originating in cone-driven retinal pathways. Brain 139:1971-86|
|Buettner, Catherine; Nir, Rony-Reuven; Bertisch, Suzanne M et al. (2015) Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol 78:970-81|
|Faria, Vanda; Erpelding, Nathalie; Lebel, Alyssa et al. (2015) The migraine brain in transition: girls vs boys. Pain 156:2212-21|
Showing the most recent 10 out of 32 publications