Abstract

We propose to develop relatively atraumatic study methods that may be applied to patients for determining accurately and precisely measurements of local cerebral function in terms of absolute values of circulation and metabolism. By means of emission computed tomography of appropriately chosen radioactive indicators given intravenously, tracer distributions will be quantified with three-dimensional localization. Once validated, these methods will be applied to improve understanding of basic human cerebral physiology and will be evaluated for their usefulness in enhancing the diagnosis and management of patients with cerebrovascular disease, seizure disorders, and metabolic encephalopathies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020867-09
Application #
3401554
Study Section
(SSS)
Project Start
1984-04-01
Project End
1989-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Organized Research Units
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Mazziotta, J C; Frackowiak, R S; Phelps, M E (1992) The use of positron emission tomography in the clinical assessment of dementia. Semin Nucl Med 22:233-46
Engel Jr, J; Bandler, R; Griffith, N C et al. (1991) Neurobiological evidence for epilepsy-induced interictal disturbances. Adv Neurol 55:97-111
Luxen, A; Perlmutter, M; Bida, G T et al. (1990) Remote, semiautomated production of 6-[18F]fluoro-L-dopa for human studies with PET. Int J Rad Appl Instrum A 41:275-81
Melega, W P; Luxen, A; Perlmutter, M M et al. (1990) Comparative in vivo metabolism of 6-[18F]fluoro-L-dopa and [3H]L-dopa in rats. Biochem Pharmacol 39:1853-60
Melega, W P; Hoffman, J M; Luxen, A et al. (1990) The effects of carbidopa on the metabolism of 6-[18F]fluoro-L-dopa in rats, monkeys and humans. Life Sci 47:149-57
Satyamurthy, N; Barrio, J R; Bida, G T et al. (1990) 3-(2'-[18F]fluoroethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in-vivo utilization in humans. Int J Rad Appl Instrum A 41:113-29
Barrio, J R; Satyamurthy, N; Huang, S C et al. (1989) 3-(2'-[18F]fluoroethyl)spiperone: in vivo biochemical and kinetic characterization in rodents, nonhuman primates, and humans. J Cereb Blood Flow Metab 9:830-9
Hawkins, R A; Huang, S C; Barrio, J R et al. (1989) Estimation of local cerebral protein synthesis rates with L-[1-11C]leucine and PET: methods, model, and results in animals and humans. J Cereb Blood Flow Metab 9:446-60
Melega, W P; Perlmutter, M M; Luxen, A et al. (1989) 4-[18F]fluoro-L-m-tyrosine: an L-3,4-dihydroxyphenylalanine analog for probing presynaptic dopaminergic function with positron emission tomography. J Neurochem 53:311-4
Keen, R E; Barrio, J R; Huang, S C et al. (1989) In vivo cerebral protein synthesis rates with leucyl-transfer RNA used as a precursor pool: determination of biochemical parameters to structure tracer kinetic models for positron emission tomography. J Cereb Blood Flow Metab 9:429-45

Showing the most recent 10 out of 27 publications