Somatosensory evoked potential (SEP) monitoring during spinal surgery has been associated with a 61% reduction in major neurological deficits. However, visual interpretation of signals is not always accurate, and a significant learning curve has been demonstrated. Therefore, we embarked on a course to develop a novel SEP monitor equipped with the latest in wireless and digital signal processing technology to continuously monitor spinal cord function. We propose the development of a toolbox of techniques which will significantly advance spinal cord assessment during surgery, including: ? Integration of noise reduction via single-sweep rejection and filtering ? Investigation of the coherence of individual spectral components of the SEP and ? Incorporation of wireless multi-channel stimulation & monitoring ? Evaluation of the resulting next-generation real-time monitor in a clinical study It is our vision to translate these hardware and software innovations into a useful device to assist the clinician in improving the outcome of the patient undergoing spinal surgery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44NS045407-03
Application #
6912727
Study Section
Special Emphasis Panel (ZRG1-BDCN-4 (10))
Program Officer
Pancrazio, Joseph J
Project Start
2003-04-01
Project End
2007-12-31
Budget Start
2005-04-01
Budget End
2007-12-31
Support Year
3
Fiscal Year
2005
Total Cost
$647,244
Indirect Cost
Name
Infinite Biomedical Technologies, LLC
Department
Type
DUNS #
037376022
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Sherman, D L; Wuyyuru, V; Brooke, M Jason et al. (2010) Spinal cord integrity monitoring by adaptive coherence measurement. J Neurosci Methods 193:90-9
Geocadin, Romergryko G; Koenig, Matthew A; Jia, Xiaofeng et al. (2008) Management of brain injury after resuscitation from cardiac arrest. Neurol Clin 26:487-506, ix
Geocadin, Romergryko G; Eleff, Scott M (2008) Cardiac arrest resuscitation: neurologic prognostication and brain death. Curr Opin Crit Care 14:261-8